Purchase of a Mass Spectrometer

化学研究仪器计划的这一奖项将帮助加州大学河滨分校(UCR)化学系购买一台高分辨率质谱仪，专门用于使用常压、化学电离/电喷雾(APCI/ESI)接口的高效液相色谱-质谱仪(HPLC-MS)和电喷雾质谱仪(ESI)分析。将开展的研究包括：(A)线性多烯的光谱；(B)在细胞抑制蛋白激酶中建立结构/功能关系；(C)酶活性部位和受体部位之间的类比；(D)新的基于膜的分析方法的开发；(E)合成和机械有机化学；(F)神经垂体肽激素和相关多肽的硫醇/二硫化学。质谱仪(MS)是一种用于探测大量有机、生物有机和有机金属分子的内部结构细节和获得其分子组成的技术。电喷雾技术的加入将MS的范围扩展到蛋白质和核酸的相对分子质量，远远超过了任何其他技术。电喷雾电离与高分辨率相结合的使用提供了质谱学中可用的最新技术。它为化学家提供了表征化合物的最强大的工具之一。在质谱学中获得这种能力对于开展许多化学领域的前沿研究是至关重要的。

This award from the Chemistry Research Instrumentation Program will aid the Chemistry Department at the University of California--Riverside (UCR) purchase a high resolution mass spectrometer dedicated to high performance liquid chromatography mass spectrometry-mass- spectrometry (HPLC-MS) and electrospray mass spectrometry analyses using atmospheric pressure, chemical ionization/electrospray (APCI/ESI) interfaces. The research studies to be performed include the following: (a) Spectroscopy of Linear Polyenes; (b) Establishing Structure/Functional Relationships in a Cytostatic Protein Kinase; (c) Analogies Between Enzyme Active Sites and Receptor Sites; (d) Development of New Membrane-Based Analytical Methods; (e) Synthetic and Mechanistic Organic Chemistry; (f) Thiol/Disulfide Chemistry of the Neurohypophyseal Peptide Hormone and Related Peptides. Mass Spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic and organometallic molecules. The addition of the technique of electrospray extends the range of MS to protein and nucleic acid molecular weights far beyond any other technique. The use of electrospray ionization in combination with high resolution provides the latest techniques available in mass spectrometry. It affords the chemist one of the most powerful tools available for the characterization of compounds. The acquisition of this capability in mass spectrometry is essential for the prosecution of frontier research in many fields of chemistry.