Collaborative Research: Improving Post-Translational Processing in Baculovirus Expression System

合作研究：改善杆状病毒表达系统的翻译后处理

• 批准号: 9412249
• 负责人: Michael Shuler
• 金额: --
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-15 至 1998-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9412249&HistoricalAwards=false
• 关键词: Collaborative; Research; Improving; Post; Translational

9412249 Shuler This project is on research to improve protein production and processing in insect cells through four goals: (1) the design of cells that are more capable of complete processing; (2) the development of improved media which mimics in vivo conditions; (3) the determination of cell culture conditions that alter intracellular protein processing; and (4) the development of improved expression vectors. This research could produce more efficient methods to produce therapeutic proteins.

9412249 Shuler这个项目是通过四个目标来提高昆虫细胞中蛋白质的生产和加工的研究：(1)设计更有能力完成加工的细胞；（二）研制模拟体内条件的改良培养基；(3)确定改变细胞内蛋白质加工的细胞培养条件；(4)改进表达载体的研制。这项研究可以产生更有效的方法来生产治疗性蛋白质。