U.S.-U.K. Cooperative Research: Structural Studies of Furoviruses

美英合作研究：糠病毒的结构研究

• 批准号: 9602486
• 负责人: Gerald Stubbs
• 金额: $ 2.19万
• 依托单位: Vanderbilt University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2001-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9602486&HistoricalAwards=false
• 关键词: U.S.; U.K.; Cooperative; Research; Structural

This three-year award supports U.S.-U.K. collaboration between Gerald J. Stubbs of Vanderbilt University and T. Michael Wilson of the Crop Research Institute in Scotland. the objective of their research is to determine the three- dimensional structure of furoviruses in molecular detail. The project is related to Dr. Stubbs research on the structure of a wide variety of different, unrelated helical plant viruses. Furoviruses have unique genetic structures, viral host interactions and transmission modes, and low levels of coat protein sequence homology with other viruses. Sequence comparisons indicate that furovirus RNA binding is very different from that of other helical viruses. The structures of these viruses will be important in understanding the nature of host-viral interactions, specificity, vector transmission, and protein-nucleic acid interactions. The U.S. investigator brings to this collaboration his expertise in structural biology. This is complemented by the U.K. investigator's expertise in virology and his research on furoviruses. The project will advance our understanding of the molecular structures of helical plant viruses and will eventually be used in applied studies of disease resistant plants.

这个为期三年的奖项支持美国-英国范德比尔特大学的Gerald J. Stubbs和T. 苏格兰作物研究所的迈克尔·威尔逊说。 他们的研究目标是从分子上详细确定糠状病毒的三维结构。 该项目与斯塔布斯博士对各种不同的、不相关的螺旋植物病毒结构的研究有关。 呋喃病毒具有独特的遗传结构、病毒宿主相互作用和传播模式，以及与其他病毒的低水平外壳蛋白序列同源性。 序列比较表明，糠病毒RNA结合是非常不同的其他螺旋病毒。 这些病毒的结构对于理解宿主-病毒相互作用、特异性、载体传播和蛋白质-核酸相互作用的性质将是重要的。 这位美国研究人员为这次合作带来了他在结构生物学方面的专业知识。 这一点得到了英国的补充。研究人员在病毒学方面的专业知识和他对糠状病毒的研究。 该项目将促进我们对螺旋植物病毒分子结构的理解，并最终用于抗病植物的应用研究。