Peripheral voltage gated sodium channels in health and disease

健康和疾病中的外周电压门控钠通道

• 批准号: G0901905-E01/1
• 负责人: John Wood
• 金额: $ 173.92万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0901905-E01%2F1
• 关键词: Peripheral; voltage; gated; sodium; channels

The present research proposal focuses on nerves found in the skin muscle and viscera that are the first stage in pathways that cause pain in the brain. In previous studies we have found some key molecules (for example Nav1.7 (a sodium channel protein) that are important pain-killing drug targets in man, by generating mice that have lost genes we think may be important in pain and modelling human disease. Here we show how we can kill different sorts of nerve cells in mice using genetically modified animals and find out what the cells do. By identifying particular cell types and associating them with different aspects of pain, we can the find the molecules that make these cells function, and devise other new pain-killing drugs taht target particular types of pain.

目前的研究计划集中在皮肤、肌肉和内脏中发现的神经上，这些神经是导致大脑疼痛的第一阶段。在以前的研究中，我们已经发现了一些关键分子（例如Nav1.7（一种钠通道蛋白）），它们是人类重要的止痛药物靶点，通过产生失去我们认为可能在疼痛和模拟人类疾病中重要的基因的小鼠。在这里，我们展示了如何使用转基因动物杀死小鼠中不同类型的神经细胞，并了解这些细胞的作用。通过识别特定的细胞类型并将它们与疼痛的不同方面联系起来，我们可以找到使这些细胞发挥功能的分子，并设计出其他针对特定类型疼痛的新型止痛药。