Gordon Conference on RNA Editing to be held on January 24-29, 1999 in Ventura, California

Gordon RNA 编辑会议将于 1999 年 1 月 24 日至 29 日在加利福尼亚州文图拉举行

• 批准号: 9818556
• 负责人: Jonatha Gott
• 金额: $ 0.5万
• 依托单位: Gordon Research Conferences
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-15 至 1999-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9818556&HistoricalAwards=false
• 关键词: Gordon; Conference; RNA; Editing; held

9818556 Gott and Hanson The Gordon Conference on RNA Editing will take place January 24-29, 1999, at the Doubletree Hotel in Ventura, California. RNA editing is the co- or post-transcriptional modification of RNA; it results in the insertion, deletion or substitution of nucleotides. RNA editing can therefore correct, extend, or diversify the information encoded within the corresponding genomic sequence and can dramatically alter the function of the modified RNA's. Equally significant is the cellular regulation of many of the RNA editing processes which provides for developmental, tissue-specific and metabolic fine-tuning of protein function and biochemical pathways. Our understanding of molecular mechanisms underlying RNA editing and their biological occurrence has reached a critical stage where cross-fertilization of hypotheses and experimental approaches is essential for focus in the next decade of research.Despite the diversity of organisms wherein editing occurs and the apparent dissimilarities in sequences which are modified, investigators of RNA editing share questions and experimental goals. Important to the understanding of every editing system is a basic description of the RNA substrates that are modified by these processes. Similarly, questions of general interest concerning the mechanism, specificity, fidelity and processivity of RNA editing can be addressed with a combination of biochemical and molecular biological techniques coupled with the development of in vitro editing systems. In this regard the cis-active regulatory elements and the relevant trans-acting factors are being evaluated at both the molecular and genetic level. Understanding the structure and function of these factors at the level of common or divergent features among the different editing systems is an important goal of this Gordon Research Conference. Still other editing systems have yet to advance to in vitro systems . This conference will foster advancement in these systems also. The biological significance of RNA editing will be emphasized throughout the conference.

9818556戈特和汉森 戈登RNA编辑会议将于1999年1月24日至29日在加州文图拉的Doubletree酒店举行。 RNA编辑是RNA的共转录或转录后修饰;它导致核苷酸的插入、缺失或取代。因此，RNA编辑可以校正、延伸或多样化相应基因组序列内编码的信息，并且可以显著改变修饰的RNA的功能。 同样重要的是许多RNA编辑过程的细胞调节，其提供蛋白质功能和生化途径的发育、组织特异性和代谢微调。我们对RNA编辑及其生物学发生的分子机制的理解已经达到了一个关键阶段，在这个阶段，假设和实验方法的交叉受精对于未来十年的研究重点至关重要。尽管编辑发生的生物体的多样性和被修饰的序列的明显差异，RNA编辑的研究人员共享问题和实验目标。 对于理解每个编辑系统来说，重要的是对这些过程修饰的RNA底物的基本描述。类似地，关于RNA编辑的机制、特异性、保真度和持续合成能力的普遍感兴趣的问题可以通过生物化学和分子生物学技术与体外编辑系统的开发相结合来解决。在这方面，顺式活性调节元件和相关的反式作用因子正在分子和遗传水平上进行评估。了解这些因素在不同编辑系统之间的共同或不同特征水平上的结构和功能是本次戈登研究会议的一个重要目标。还有其他编辑系统尚未发展到体外系统。这次会议也将促进这些系统的发展。 RNA编辑的生物学意义将在整个会议中得到强调。