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Activating Biocatalysts for Nonaqueous and Combinatorial Reactions

Activating Biocatalysts for Nonaqueous and Combinatorial Reactions
活化非水反应和组合反应的生物催化剂
批准号：
9902878
负责人：
Douglas Clark
金额：
$25.44万
依托单位：
University of California-Berkeley
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-01-15 至 2002-12-31
来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=9902878&HistoricalAwards=false
关键词：
ActivatingBiocatalystsNonaqueousCombinatorialReactions

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英文摘要
This proposal pursues an older observation that the lyophilization of certain enzyme catalysts in the presence of highly ionic, non-buffering salts, e.g., KCl, can increase the catalytic rate in non-aqueous systems by 3-4 orders of magnitude. This has been demonstrated primarily on subtilisin. The specific aims of the original proposal are: To elucidate the mechanism(s) of enzyme activation in organic solvents with saltsTo extend the concept to a broad range of enzymes and reactions. To utilize the activated enzymes for combinatorial biocatalysis. In the revised and funded proposal, Aim 3 has been dropped and a more detailed examination of the mechanism and scope of the phenomenon has been added.
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