CONFERENCE: Cold Spring Harbor Laboratory Conference on Zebrafish Development & Genetics; April 26-30, 2000, in Cold Spring Harbor(Nassau County), New York

该提案请求支持第四次斑马鱼发育和遗传学公开邀请会议。会议将集中讨论斑马鱼的发育生物学、遗传学和基因组学。它将强调斑马鱼发育和生长的细胞、分子和遗传调节，斑马鱼是唯一进行了系统的大规模胚胎致命突变筛查的脊椎动物。计划举行以下会议：1)早期发育和模式I；2)神经发育；3)轴突寻路；4)神经脊和感觉器官；5)基因组学和遗传策略；6)方法和新技术；7)细胞分化；8)细胞命运选择；9)细胞信号；10)组织和器官模式；11)斑马鱼作为人类疾病的模型。主旨演讲将由一位研究人员发表，他的主要兴趣不是斑马鱼，但他可能会激励斑马鱼工作者拓宽他们的思维方式，思考他们处理研究主题的方式。拟议的会议将吸引来自大多数斑马鱼实验室的成员，并将提供一个开放的场所，介绍最新的研究成果。它还将为交流有关不断发展的技术和方法的材料和信息提供机会。约480人参加了上一次会议，来自26个国家的调查人员介绍了情况。

The proposal requests support for the fourth bi-annual open-invitation Conference on Zebrafish Development and Genetics. The meeting will focus on the developmental biology, genetics and genomics of the zebrafish. It will emphasize the cellular, molecular, and genetic regulation of development and growth in zebrafish, the only vertebrate in which systematic large scale screens for embryonic lethal mutations have been conducted. The following sessions are planned: 1) Early development and patterning I; 2) Neural development; 3) Axonal pathfinding; 4) Neural crest and sensory organs; 5) Genomics and genetic strategies; 6) Methods and new technology; 7) Cell differentiation; 8) Cell fate choices; 9) Cell signalling; 10) Tissue and organ patterning; and 11) Zebrafish as a model for human disease. The Keynote address will be given by an investigator whose primary interest is not zebrafish, but who is likely to stimulate zebrafish workers to broaden their ways of thinking about the ways they approach their research topic. The proposed meeting will attract members from most zebrafish laboratories, and will provide an open arena for the presentation of the latest research results. It will also provide an opportunity for the exchange of materials and information about evolving technologies and methodological approaches. About 480 people attended the previous meeting and presentations were given by investigators from 26 countries.