Upgrade of a 500 MHz NMR Spectrometer

哥伦比亚大学化学系将利用化学研究仪器和设施（CRIF）项目的这笔资金升级一台500 MHz核磁共振光谱仪。该设备将促进以下领域的研究：a)使用纳米至微克量的配体进行结构、立体化学或配体/受体相互作用的微尺度测定；B)螺旋共轭分子的研究；C)开发基于催化活性的体内蛋白质遗传筛选；D)从头蛋白设计；e)合成具有有趣性质的分子，例如在体内选择性结合和水解可卡因的催化剂。核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。这些核磁共振研究的结果将对包括生物化学和合成化学在内的许多领域产生影响。

With this award from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at Columbia University will upgrade a 500 MHz NMR Spectrometer. This equipment will facilitate research in the following areas: a) microscale determinations of structures, stereochemistry or ligand/receptor interactions using nano- to micro-gram amounts of ligands; b) studies of helical conjugated molecules; c) development of a genetic screen for proteins in vivo based on catalytic activity; d) de novo protein design; and e) synthesis of molecules with interesting properties, such as a catalyst that selectively binds and hydrolyzes cocaine in vivo. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in a number of areas including biochemistry and synthetic chemistry.