Microbial Genome Sequencing: Genome Sequence of Magnaporthe Grisea

微生物基因组测序：稻瘟病菌基因组序列

• 批准号: 0136064
• 负责人: Ralph Dean
• 金额: $ 70万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-10-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0136064&HistoricalAwards=false
• 关键词: Microbial; Genome; Sequencing; Sequence; Magnaporthe

Rice blast disease, caused by the fungal pathogen Magnaporthe grisea, is a major threat to food security worldwide. Decades of intense investigation have proven the fungus to be eminently suitable for genetic and molecular genetic manipulation, making it the primary model for elucidating the basis of phytopathogenesis, including infection related morphogenesis and cultivar/host range specificity. The Magnaporthe research community has established an international consortium with the goal of obtaining a complete genome sequence of the fungus. The community has also developed numerous biological resources and tools to take immediate advantage of the sequence. This project represents a partnership between North Carolina State University and the Whitehead Institute-Center for Genome Research to generate and assemble the entire genome using a whole genome shotgun approach and to perform automated annotation. The rapid availability of this sequence in an annotated form will immediately provide new opportunities for integrating research and education of students. The data will promote the discovery of genes and potential anti-fungal targets, permit reconstruction of pathways, provide sequence-anchored clone paths for use in genetic and functional studies, and enable comparative genomic approaches to commence. Moreover, the data will provide the foundation for the discovery and design of novel environmentally sound strategies to more effectively manage this and other fungal diseases. This is a Microbial Genome Sequencing Award funded through a collaborative activity between the National Science Foundation and the Department of Agriculture Initiative for Future Agriculture and Food Systems. This award represents one portion of the Magnaporthe grisea genome sequencing project. The other portion is being funded by the USDA.

由稻瘟病菌引起的稻瘟病是世界粮食安全的主要威胁。 几十年的深入研究已经证明该真菌非常适合遗传和分子遗传操作，使其成为阐明植物病原学基础的主要模型，包括感染相关的形态发生和品种/宿主范围特异性。 Magnaporthe研究界已经建立了一个国际财团，目标是获得该真菌的完整基因组序列。 该社区还开发了许多生物资源和工具，以立即利用该序列。 该项目代表了北卡罗来纳州州立大学和怀特黑德研究所基因组研究中心之间的合作伙伴关系，使用全基因组鸟枪法生成和组装整个基因组，并进行自动注释。 这一序列的注释形式的快速可用性将立即为整合研究和学生教育提供新的机会。 这些数据将促进基因和潜在抗真菌靶点的发现，允许重建途径，提供用于遗传和功能研究的序列锚定克隆路径，并使比较基因组方法能够开始。 此外，这些数据将为发现和设计新的环境无害化策略提供基础，以更有效地管理这种和其他真菌疾病。这是一个微生物基因组测序奖，由美国国家科学基金会和农业部未来农业和食品系统倡议之间的合作活动资助。 该奖项代表了稻瘟病菌基因组测序项目的一部分。 另一部分由美国农业部资助。