MRI: ACQUISITION OF A MULTI-FUNCTIONAL ELECTRON MICROSCOPE FOR STUDIES AT THE NANO/MICRO SCALE IN THE MATERIAL AND LIFE SCIENCES

磁共振成像：获得用于材料和生命科学纳米/微观尺度研究的多功能电子显微镜本提案的目的是获得一台环境场发射扫描/透射电子显微镜（E-FE-S/TEM），以满足密苏里大学在纳米技术、材料科学和生命科学方面的广泛研究和教育需求。该仪器包括SEM和STEM成像与一套分析组件和电子束光刻图案低至20纳米。实现目标的方法将是将仪器整合到现有的校园电子显微镜核心设施中，该设施将维护并提供设备的访问权限。E-FE-S/TEM将允许研究人员在不改变其特性的情况下对生物细胞、抗体、肽等进行成像。它还将允许用户对具有纳米级特征的半导体进行图案、成像和分析。需要该仪器的样品项目包括：生物分子介导的纳米阵列制造，细胞膜上蛋白质纳米孔的形成，微dna合成和分析系统，以及金属颗粒诱导的巨介电常数。该仪器将使科学家们能够提高我们对自然世界的理解，并以其他方法和仪器无法实现的方式制造纳米级设备。它将用于培训新科学家使用有利于工程、环境和生命科学的工具。新的研究领域，如生物传感器的开发，将通过使用这种仪器打开。在这种设备的帮助下，很可能会产生许多有益于社会的进步。在预期的进步中，包括那些将改善国家安全、环境和公共安全的进步。

MRI: ACQUISITION OF A MULTI-FUNCTIONAL ELECTRON MICROSCOPE FOR STUDIES AT THE NANO/MICRO SCALE IN THE MATERIAL AND LIFE SCIENCESThe objective of this proposal is the acquisition of an Environmental Field Emission Scanning/Transmission Electron Microscope (E-FE-S/TEM) to address broad research and educational needs in nanotechnology, materials science, and life sciences at the University of Missouri. The instrument includes both SEM and STEM imaging with a suite of analytical components and E-beam lithographic patterning down to 20 nm. The approach to accomplishing the objective will be to integrate the instrument into the existing campus Electron Microscopy Core Facility, which will maintain and provide access to the equipment.The E-FE-S/TEM will allow researchers to image biological cells, antibodies, peptides, etc. without altering their properties. It will also allow users to pattern, image and analyze semiconductors with nanoscale features. Sample projects requiring this instrument include: biomolecule-mediated fabrication of nanoarrays, formation of protein nanopores on cell membrane, micro-DNA synthesis and analysis systems, and metal particle induced giant permittivity. The instrument will enable scientists to advance our understanding of the natural world and to fabricate devices at the nanoscale in ways not possible with other approaches and instruments. It will be used to train new scientists in the use of tools that will benefit engineering, the environment, and the life sciences. New fields of study, such as biosensor development, will be opened up through use of this instrumentation. It is likely that numerous advances that will benefit society will be developed with the aid of this equipment. Among the anticipated advances are those that would improve national security, the environment, and public safety.