Multivalent "Artificial Antibody" Based on RNA/Dendrimer-Like Star Polymer Hybrid Nanomaterials

基于RNA/类树枝状聚合物星形聚合物杂化纳米材料的多价“人工抗体”

基本信息

  • 批准号:
    0705716
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-07-01 至 2010-12-31
  • 项目状态:
    已结题

项目摘要

This award to University of Connecticut by the Biomaterials program in the Division of Materials Research is to study the multivalent artificial antibody based on conjugates of RNA aptamers and biodegradable dendrimer-like star polymers, and to prove the concept that these novel nanobiomaterials have properties of antibodies. Earlier studies have demonstrated that RNA aptamers, which are of smaller size than antibody show minimal immunogenicity, unique binding specificity and affinity, and excellent chemical and biological stability. The proposal includes design and synthesis of biodegradable dendrimer star-like polymers, conjugation of RNA aptamers to the polymer, and functional characterization of these polymer-RNA conjugates. Antibodies are natural nanomaterials that have been developed over a long-term evolution of life. Because of their high affinity and specificity to antigens, antibodies have been used in various areas. Many applications, however, can be significantly hindered because of their immunogenicity, relatively large molecular size, and low chemical and biological stability during manufacturing, shipping, storage and chemical bioconjugation, etc. The synthetic antibodies that being synthesized are expected to possess superior features such as smaller size than natural antibody, environmentally stable structure, tunable biodegradability, and biocompatible property. The knowledge developed from these studies would be useful for various technological applications, e.g., targeted drug delivery, diagnosis and biodetection. The scientific impact in the development of artificial antibodies would be an enormous breakthrough, and would have huge impacts in the fields of drug delivery, vaccine development and drug targeting among others. With this award, Professors Wang and Zhu plan to develop a new course in nanobiomaterials and nanomedicine with hands on laboratory for undergraduate students. As part of the outreach program and as part of the Da Vinci program at the University, the investigators will utilize one week training camp for teachers to expose them to the cutting edge of bionanomaterials. Research results will be broadly disseminated by collaborations with industries through the Associate Programs at the Institute of Materials Science, as well as by publications in quality peer-reviewed journals and presentations at national and international meetings.
康涅狄格大学材料研究部生物材料项目的这一奖项是为了研究基于RNA适体和可生物降解的树枝状星星状聚合物的缀合物的多价人工抗体,并证明这些新型纳米生物材料具有抗体性质的概念。 早期的研究已经证明,RNA适体,其尺寸小于抗体,显示出最小的免疫原性,独特的结合特异性和亲和力,以及优异的化学和生物稳定性。 该提案包括设计和合成的可生物降解的树状星形聚合物,共轭的RNA适体的聚合物,这些聚合物-RNA共轭物的功能表征。抗体是在生命的长期进化中开发出来的天然纳米材料。 由于其对抗原的高亲和力和特异性,抗体已被用于各个领域。 然而,由于其免疫原性、相对大的分子尺寸以及在制造、运输、储存和化学生物缀合等过程中的低化学和生物稳定性,许多应用可能会受到显著阻碍。合成的合成抗体被期望具有上级特征,例如比天然抗体更小的尺寸、环境稳定的结构、可调节的生物降解性和生物相容性。 从这些研究中获得的知识将有助于各种技术应用,例如,靶向药物输送、诊断和生物检测。 人工抗体开发的科学影响将是一个巨大的突破,并将在药物输送、疫苗开发和药物靶向等领域产生巨大影响。 有了这个奖项,王教授和朱教授计划开发一个新的课程,在纳米生物材料和纳米医学与实验室的本科生。作为推广计划的一部分,也是大学达芬奇计划的一部分,研究人员将利用为期一周的教师培训营,让他们接触生物纳米材料的最前沿。 研究成果将通过材料科学研究所的副项目与行业合作,以及在高质量的同行评审期刊上发表文章和在国家和国际会议上发表演讲而广泛传播。

项目成果

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Yong Wang其他文献

Enhancing heat production by managing heat and water flow in confined geothermal aquifers
通过管理承压地热含水层中的热量和水流来提高产热能力
  • DOI:
    10.1016/j.renene.2019.03.147
  • 发表时间:
    2019-11
  • 期刊:
  • 影响因子:
    8.7
  • 作者:
    Zhenjiao Jiang;Tianfu Xu;Yong Wang
  • 通讯作者:
    Yong Wang
Propofol affects mouse embryonic fibroblast survival and proliferation in vitro via ATG5- and calcium-dependent regulation of autophagy
异丙酚通过 ATG5 和钙依赖性自噬调节影响体外小鼠胚胎成纤维细胞的存活和增殖
  • DOI:
    10.1038/s41401-019-0303-z
  • 发表时间:
    2019-10
  • 期刊:
  • 影响因子:
    8.2
  • 作者:
    Zhen-dong Xu;Yong Wang;Ge Liang;Zhi-qiang Liu;Wu-hua Ma;Charleen T Chu;Hua-feng Wei
  • 通讯作者:
    Hua-feng Wei
Numerical Investigation on Wave Drag Reduction by Laser Energy Deposition
激光能量沉积减阻波阻的数值研究
  • DOI:
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Xiaojing Yu;Hong Yan;Yong Wang
  • 通讯作者:
    Yong Wang
Retraction Note to: SELP genetic polymorphisms may contribute to the pathogenesis of coronary heart disease and myocardial infarction: a meta-analysis
撤回注释:SELP 基因多态性可能有助于冠心病和心肌梗死的发病机制:一项荟萃分析
  • DOI:
    10.1007/s11033-015-3888-4
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    2.8
  • 作者:
    Donghui Zhou;Yong Wang;Wei;Li;Qi Wang;M. Chi;Yuanzhe Jin
  • 通讯作者:
    Yuanzhe Jin
Clinical and Population Studies Deficient CD 4 CD 25 T Regulatory Cell Function in Patients With Abdominal Aortic Aneurysms
腹主动脉瘤患者 CD 4 CD 25 T 调节细胞功能缺陷的临床和人群研究
  • DOI:
  • 发表时间:
    2010
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Ming;Jian Zhang;Yong Wang;Shao;D. Böckler;Z. Duan;S. Xin
  • 通讯作者:
    S. Xin

Yong Wang的其他文献

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{{ truncateString('Yong Wang', 18)}}的其他基金

I-Corps: Development of Bent DNA Molecules as Amplifying Sensors
I-Corps:开发弯曲 DNA 分子作为放大传感器
  • 批准号:
    2129225
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
IIBR Instrumentation: Collaborative Research: Development of a Single-Biomolecule Detection Instrument via Digital Counting of Nanoparticles
IIBR Instrumentation:合作研究:通过纳米颗粒数字计数开发单生物分子检测仪器
  • 批准号:
    1911764
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
REU Site in IoT Security
物联网安全领域的 REU 站点
  • 批准号:
    1852145
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Understanding the antimicrobial mechanism of metal nanoparticles using super resolution fluorescence microscopy
使用超分辨率荧光显微镜了解金属纳米颗粒的抗菌机制
  • 批准号:
    1826642
  • 财政年份:
    2018
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Growth of Hybrid Polymeric Nanostructures for Enzyme-Free Amplified Protein Imaging
用于无酶放大蛋白质成像的混合聚合物纳米结构的生长
  • 批准号:
    1802953
  • 财政年份:
    2018
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
UKCRIC National Centre for Infrastructure Materials - Extreme Loading Facilities
UKCRIC 国家基础设施材料中心 - 极限负载设施
  • 批准号:
    EP/P017061/1
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
    Research Grant
Structural and Fire Resistance of a Reusable Steel/Concrete Composite Floor System
可重复使用的钢/混凝土复合地板系统的结构和防火性能
  • 批准号:
    EP/N01135X/1
  • 财政年份:
    2016
  • 资助金额:
    --
  • 项目类别:
    Research Grant
MRI: Acquisition of Equipment to Establish Mobile Testing Infrastructure for Bring Your Own Device Research and Education
MRI:采购设备以建立移动测试基础设施,以便自带设备进行研究和教育
  • 批准号:
    1337529
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
CAREER: Creation of Complex Biomimetic Materials via Molecular Recognition
职业:通过分子识别创建复杂的仿生材料
  • 批准号:
    1332351
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant
Reversible Cell Capture and Release for Cell Separation
用于细胞分离的可逆细胞捕获和释放
  • 批准号:
    1340173
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
    Standard Grant

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人工抗体包被酶材料的研制及其在食品成分比色/荧光分析新方法中的应用
  • 批准号:
    19K05527
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    2019
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基于抗体结构域高阶结构特异性的人工蛋白对治疗性抗体进行质量控制监测
  • 批准号:
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绿色荧光蛋白单链人工抗体肿瘤可视化系统的构建及临床应用
  • 批准号:
    17K10685
  • 财政年份:
    2017
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使用分子印迹聚合物纳米复合材料作为人工抗体识别和传感含氟有机化合物
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    17K05916
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利用随机氨基酸序列库开发抗苦味受体人工抗体
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易损动脉粥样硬化斑块的特异性成像:使用低分子人工抗体开发新型 SPECT 探针
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将过渡金属化合物引入特制人工酶(催化抗体)抗原结合位点的研究
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