RI: Robust Robotic System for Live Microarrays in Life Sciences

RI：生命科学中活体微阵列的鲁棒机器人系统

• 批准号: 0712845
• 负责人: Yuan Zheng
• 金额: --
• 依托单位: Ohio State University Research Foundation -DO NOT USE
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0712845&HistoricalAwards=false
• 关键词: RI; Robust; Robotic; System; Live

A completely new focus in robotics research is proposed. The purpose is to enable automatic dispensing and mixing of highly viscous bio-samples which has important applications in life sciences including drug screening, protein crystallization, and protein expression. Since the volume to deal with is extremely small at the micro- or nano-liter scale, and viscosity causes the samples to stick to everything, robotic handling of such bio-samples is extremely challenging. Three novel methods are proposed to solve the problems. The first method is an innovative micro-capsule with micro-channel for mixing viscous bio-samples using centrifugation such that no contact is needed. The second method is soft-hard compliance of robotic motion for delivering bio-samples into tiny micro-capsules, for which a micro force-sensing device based on piezo-resistance and visco-elasticity is to be invented. The third method is a programmable robotic spinning device which generates adequate centrifugal forces in real-time for mixing bio-samples. The three new methods will lay a foundation for high-throughput dispensing and mixing of bio-samples using robust intelligence in robotics. In addition, the project will bring a broader impact to life sciences, education, and economy.

提出了机器人研究的一个全新的焦点。 其目的是实现高粘度生物样品的自动分配和混合，这在生命科学中具有重要的应用，包括药物筛选、蛋白质结晶和蛋白质表达。 由于在微升或纳升尺度下要处理的体积非常小，并且粘度导致样品粘在所有东西上，因此机器人处理此类生物样品极具挑战性。 提出了三种新的方法来解决这些问题。 第一种方法是具有微通道的创新微胶囊，用于使用离心混合粘性生物样品，使得不需要接触。 第二种方法是机器人运动的软硬顺应性，用于将生物样品送入微小的微胶囊中，为此，将发明基于压阻和粘弹性的微力传感装置。 第三种方法是可编程机器人旋转装置，其实时产生足够的离心力以混合生物样品。 这三种新方法将为使用机器人技术中强大的智能来高通量分配和混合生物样品奠定基础。 此外，该项目将对生命科学、教育和经济产生更广泛的影响。