NSF/FDA Scholar-in-Residence at FDA

NSF/FDA FDA 常驻学者

• 批准号: 0717830
• 负责人: James Miller
• 金额: $ 24.06万
• 依托单位: Washington University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0717830&HistoricalAwards=false
• 关键词: NSF; FDA; Scholar; Residence

0717830MillerThe proposed research is designed to enhance the knowledge base underpinning ultrasonic devices for the diagnosis of bone and heart disease. The premise is that expanding the knowledge base will permit the understanding of basic mechanisms by which such ultrasonic instruments interrogate the tissue. A broader goal of this proposal is the support of the FDA in its mission to facilitate the introduction of new, safe, and effective medical devices into clinical practice. The proposed work is structured to permit the integration of research and education by enabling a professor of physics and graduate students from Washington University in St. Louis to participate in research collaborations within the intramural research environment at the FDA. Ultrasound is the specific area of research targeted for this collaboration, which is designed to contribute to the generation of new knowledge underpinning the development of devices for improved assessment of bone quality and advances in myocardial tissue characterization as an adjunct to echocardiography. Research projects dealing with bone disease will include (1) the effects on diagnostic measuring devices of the potential interference of fast wave and slow wave compressional ultrasonic modes and (2) the impact on diagnostic measurements of phase aberration and phase cancellation at phase sensitive ultrasonic receiving transducer apertures. The potential impact of the results of these studies on diagnostic measurements of bone will be evaluated in part with the aid of microcomputed tomography (microCT) and mechanical testing of bone samples. Projects related to heart will focus on identifying and refining methods to combine multiple features derived from myocardial backscatter. At the present time, most laboratories report only the magnitude of the cyclic variation of backscatter. Additional features that are expected to improve the basis for diagnosis include the time delay of the cyclic variation relative to cardiac systole, the duty cycle of the cyclic variation waveform, and the time rate of change of backscatter during the cyclic variation.

0717830 Miller拟议的研究旨在增强支持超声器械诊断骨骼和心脏疾病的知识库。 其前提是，扩大知识基础将允许理解的基本机制，通过这种超声仪器询问组织。本提案的一个更广泛的目标是支持FDA履行其使命，促进将新的、安全有效的医疗器械引入临床实践。拟议工作的结构允许研究和教育的整合，使物理学教授和圣路易斯华盛顿大学的研究生能够参与FDA内部研究环境中的研究合作。 超声是此次合作的特定研究领域，旨在促进新知识的产生，以支持开发用于改善骨质量评估的设备，并作为超声心动图的辅助手段在心肌组织定征方面取得进展。与骨骼疾病有关的研究项目将包括：（1）快波和慢波压缩超声模式的潜在干扰对诊断测量设备的影响;（2）相位敏感超声接收换能器孔径处的相位畸变和相位抵消对诊断测量的影响。这些研究结果对骨诊断测量的潜在影响将部分借助骨样本的微计算机断层扫描（microCT）和机械测试进行评价。与心脏相关的项目将侧重于识别和改进方法，以结合联合收割机的多种功能，从心肌背向散射。目前，大多数实验室仅报告反向散射的周期变化的幅度。预期改善诊断基础的附加特征包括循环变化相对于心脏收缩的时间延迟、循环变化波形的占空比以及循环变化期间反向散射的时间变化率。