MRI: Acquisition of a 600 Mhz NMR Spectrometer at the University of Southern California

在美国国家科学基金会的磁共振成像项目下，南加州大学在理查德·W·戈恩博士的监督下获得了一笔赠款。罗伯茨和马克·汤普森博士 这笔赠款的资金将用于购买南加州大学所有部门都可以使用的600 MHz NMR光谱仪。核磁共振光谱（也称为NMR）可以说是研究分子的最通用的技术。 该仪器将使南加州大学的科学家能够确定分子的结构和运动，其细节小于十亿分之一米，即一纳米。因此，该仪器将对南加州大学在1.生物医学纳米科学，2。图像，3。能源 特别是，该仪器将用于1）确定生物分子的结构（DNA，RNA和蛋白质），用于基础研究，新疗法和诊断，2）检查生物分子的运动，3）测量药物和药物样分子与其治疗靶点的相互作用，4）非常详细地研究化学反应，5）探索与能源生产相关的新化学方法和新材料。 在此之前，南加州大学缺乏一个开放的用户设施的现代生物分子核磁共振。 因此，这一工具的第一个影响将是为参与这一项目的用户群体提供一个新的培训和研究工具。这包括18名教师，14名本科生，104名研究生和54名博士后，分布在南加州大学的6个学术部门和5所学校。其次，这笔赠款将使南加州大学能够建立一个通用的结构生物学座谈会，将这种仪器（NMR）与用于确定分子结构的其他方法（如X射线晶体学）相结合。 最后，该工具将被用作招聘和培训工具，并用于USC TRIO和USC梅萨计划，旨在为弱势，以科学为导向的高中三年级和四年级学生提供服务。

A grant has been awarded under the NSF's MRI program to the University of Southern California under the supervision of Dr. Richard W. Roberts and Dr. Mark Thompson. Funds from this grant will be used to purchase a 600 MHz NMR spectrometer that will be accessible to all departments at USC. Nuclear Magnetic Resonance spectroscopy (also known as NMR) is arguably the most versatile technique available for studying molecules. This instrument will allow scientists at USC to determine the structures and movements of molecules with detail down to less than 1 billionth of a meter, a nanometer. As such, this instrument will have a major positive impact on USC's scientific goals in the areas of 1. Biomedical Nanoscience, 2. Imaging, and 3. Energy. In particular, the instrument will be used 1) to determine the structures of biological molecules (DNA, RNA and proteins) needed for basic research, new therapies, and diagnostics, 2) to examine the motions of biological molecules, 3) to measure the interactions of drugs and drug-like molecules with their therapeutic targets, 4) to study chemical reactions in great detail, and 5) to explore new chemical methods and materials relevant to energy production. Prior to this grant, USC lacked a modern biomolecular NMR in an open user facility. The first impact of this instrument will thus be to provide a new training and research tool for user groups involved in this project. This includes 18 faculty, 14 undergraduates, 104 graduate students and 54 postdocs across 6 academic departments and 5 schools within USC. Second, this grant will enable establishing a general structural biology colloquia at USC integrating this instrument (NMR) with other methods used to determine the structures of molecules, such as X-ray crystallography. Finally, this instrument will be used as a recruiting and training tool and for the USC TRIO and USC MESA programs aimed at serving disadvantaged, science-oriented high school juniors and seniors.