MRI: Acquisition of a Field Emission Cryo-Scanning Electron Microscope for Nanocharacterization and Patterning of Soft Materials
MRI:获取场发射冷冻扫描电子显微镜,用于软材料的纳米表征和图案化
基本信息
- 批准号:0922522
- 负责人:
- 金额:$ 69.98万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-10-01 至 2012-09-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
0922522LiberaStevens Institute of TechnologyTechnical Summary: This project applies a new, state-of-the-art, cryo-scanning electron microscope (SEM) to measure soft-materials morphology at high spatial resolution. This new microscope will advance over ten research projects at Stevens Institute of Technology and enable them to follow important directions that amplify their ongoing and anticipated aims. All involve soft materials ? either synthetic polymers, biological structures, or combinations of the two. Among the materials being studied are: self-assembled, weak-polyelectrolyte, responsive micelles; nanoparticle composites; degradable scaffolds that mimic natural bone; infection-resistant orthopedic implants; natural extracellular matrix; and synthetic nanofiber extracellular matrices. Synthetic and natural polymers are challenging materials to study by electron microscopy because of their radiation sensitivity, weak intrinsic contrast, and susceptibility to electrical charging. This new microscope provides controllable electron accelerating voltages enabled at low voltages by a field-emission (FEG) electron source; gas compensation to mitigate specimen charging; high-efficiency electron detectors that minimize the required incident dose; robust methods for digital image acquisition/processing; cryo-imaging capabilities for studying frozen-hydrated materials; and hardware/software for robust electron-beam lithography. All of these features are either inadequate or unavailable on the SEM the new microscope replaces. Importantly, the new SEM is housed in a central user facility with a history of successful multidisciplinary training that spans high school through post-graduate school. Users receive substantial training both by concentrated hands-on self-user practice and by graduate lecture/lab course work. In addition to serving the immediate Stevens research community, the instrument plays an important role in community outreach and education by way of collaborative activities with the Stevens Center for Innovative Engineering and Science Education, an established K-16 outreach organization, and the Project SEED program of the American Chemical Society.Layman Summary: Scanning electron microscopes (SEMs) are used to study the surfaces of materials at magnifications between about 20 and 500,000 times. They can provide important information about the structure and composition of materials. So-called soft materials, such as plastics and biological tissue, are typically more challenging to study by electron microscopy than metals or semiconductors, because soft materials can become both electrically charged and chemically changed by the electrons used in the microscope. At Stevens Institute of Technology there are more than ten research projects, all of which involve soft materials, whose progress is limited by the need to do more and better SEM imaging and analysis. The newest scanning electron microscopes incorporate innovative features that can help Stevens researchers overcome the problems of specimen charging and chemical damage. To take advantage of these, this project is using a new, state-of-the-art, SEM to measure soft-materials morphology and help Stevens researchers make new discoveries. These scientists are, for example, using the microscope to develop new ways to delivery drugs, to make hip and knee implants more infection resistant, and to help heal major bone fractures. Because this new microscope is a complex instrument, it is housed in a laboratory with a dedicated staff and facilities to both maintain the microscope and provide the advanced training needed for university students to make the best use of this new tool. Importantly, however, many aspects of the microscope are relatively easy to use and understand, so this microscope is also helping Stevens develop connections to the surrounding community through a variety of high-school outreach programs designed to get more young people aware of and interested in science and engineering.
0922522利伯拉史蒂文斯理工学院技术摘要:该项目应用新型、最先进的冷冻扫描电子显微镜 (SEM) 以高空间分辨率测量软材料形态。 这款新型显微镜将推进史蒂文斯理工学院的十多个研究项目,并使他们能够遵循重要方向,扩大他们正在进行和预期的目标。 全部涉及软质材料?合成聚合物、生物结构或两者的组合。 正在研究的材料包括:自组装、弱聚电解质、响应性胶束;纳米粒子复合材料;模仿天然骨骼的可降解支架;抗感染骨科植入物;天然细胞外基质;和合成纳米纤维细胞外基质。 合成和天然聚合物是电子显微镜研究中具有挑战性的材料,因为它们的辐射敏感性、弱的固有对比度和对电荷的敏感性。这种新型显微镜可通过场致发射 (FEG) 电子源在低电压下提供可控电子加速电压;气体补偿以减轻样品充电;高效电子探测器,最大限度地减少所需的入射剂量;数字图像采集/处理的稳健方法;用于研究冷冻水合材料的冷冻成像能力;以及用于稳定电子束光刻的硬件/软件。 所有这些功能在新显微镜所取代的 SEM 上要么不充分,要么不可用。 重要的是,新的 SEM 坐落在一个中央用户设施中,该设施拥有从高中到研究生院的成功多学科培训历史。 用户通过集中的亲身实践和研究生讲座/实验室课程作业接受大量培训。 除了为史蒂文斯研究社区提供服务外,该仪器还通过与史蒂文斯创新工程和科学教育中心(一个已建立的 K-16 外展组织)以及美国化学会 SEED 项目的合作活动,在社区外展和教育方面发挥着重要作用。外行摘要:扫描电子显微镜 (SEM) 用于以大约 20 至 500,000 倍的放大倍数研究材料表面。 它们可以提供有关材料结构和成分的重要信息。 塑料和生物组织等所谓的软材料通常比金属或半导体更难以通过电子显微镜进行研究,因为软材料可能会因显微镜中使用的电子而带电并发生化学变化。 史蒂文斯理工学院有十多个研究项目,全部涉及软材料,但由于需要进行更多更好的扫描电镜成像和分析,其进展受到限制。 最新的扫描电子显微镜具有创新功能,可以帮助史蒂文斯研究人员克服样品带电和化学损伤的问题。 为了利用这些优势,该项目正在使用最先进的新型 SEM 来测量软材料形态并帮助史蒂文斯研究人员取得新发现。 例如,这些科学家正在利用显微镜开发新的药物输送方法,使髋关节和膝关节植入物更具抗感染性,并帮助治愈主要骨折。 由于这种新型显微镜是一种复杂的仪器,因此它被安置在一个拥有专门人员和设施的实验室中,以维护显微镜并为大学生提供充分利用这种新工具所需的高级培训。 然而,重要的是,显微镜的许多方面都相对容易使用和理解,因此这款显微镜还帮助史蒂文斯通过各种高中外展项目建立与周围社区的联系,这些项目旨在让更多的年轻人了解科学和工程并对科学和工程感兴趣。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Matthew Libera其他文献
Multilayered Thin-Film Materials for Phase-Change Erasable Storage
- DOI:
10.1557/s0883769400059947 - 发表时间:
2013-11-29 - 期刊:
- 影响因子:4.900
- 作者:
Matthew Libera;Martin Chen - 通讯作者:
Martin Chen
Effects of implantation temperature on the structure, composition, and oxidation resistance of aluminum-implanted SiC
- DOI:
10.1557/jmr.1995.1441 - 发表时间:
2011-03-03 - 期刊:
- 影响因子:2.900
- 作者:
Zunde Yang;Honghua Du;Matthew Libera;Irwin L. Singer - 通讯作者:
Irwin L. Singer
The 2023 Orthopedic Research Society's international consensus meeting on musculoskeletal infection: Summary from the in vitro section
2023年骨科研究会肌肉骨骼感染国际共识会议:体外部分总结
- DOI:
10.1002/jor.25774 - 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Noreen J. Hickok;Bingyun Li;Ebru Oral;S. Zaat;David A. Armbruster;Gerald J. Atkins;Antonia F. Chen;Débora C. Coraça‐Huber;Tianhong Dai;Edward M. Greenfield;Rajendra Kasinath;Matthew Libera;Cláudia N H Marques;T. Fintan Moriarty;K. Scott Phillips;Kapil Raghuraman;Dacheng Ren;Lia Rimondini;K. Saeed;Thomas P. Schaer;Edward M. Schwarz;Christopher Spiegel;P. Stoodley;Vi Khanh Truong;Shao‐Ting Jerry Tsang;B. Wildemann;A. R. Zelmer;A. Zinkernagel - 通讯作者:
A. Zinkernagel
Matthew Libera的其他文献
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{{ truncateString('Matthew Libera', 18)}}的其他基金
Conference: The 6th Stevens Conference on Bacteria-Material Interactions
会议:第六届史蒂文斯细菌-材料相互作用会议
- 批准号:
2309091 - 财政年份:2023
- 资助金额:
$ 69.98万 - 项目类别:
Standard Grant
Collaborative Research: GCR: Infection-Resisting Resorbable Scaffolds for Engineering Human Tissue
合作研究:GCR:用于工程人体组织的抗感染可吸收支架
- 批准号:
2219014 - 财政年份:2022
- 资助金额:
$ 69.98万 - 项目类别:
Continuing Grant
The 5th Stevens Conference on Bacteria-Material Interactions
第五届史蒂文斯细菌-材料相互作用会议
- 批准号:
1907604 - 财政年份:2019
- 资助金额:
$ 69.98万 - 项目类别:
Standard Grant
MRI: Acquisition of a Transmission Electron Microscope for Materials Research
MRI:购买透射电子显微镜用于材料研究
- 批准号:
1827557 - 财政年份:2018
- 资助金额:
$ 69.98万 - 项目类别:
Standard Grant
Bacteria-Triggered Antimicrobial Release from Microgel-Modified Surfaces
微凝胶改性表面的细菌触发抗菌剂释放
- 批准号:
1608406 - 财政年份:2016
- 资助金额:
$ 69.98万 - 项目类别:
Continuing Grant
Microgel Tethering for Integrated Microarray-Based RNA Amplification and Detection
用于基于微阵列的集成 RNA 扩增和检测的微凝胶束缚
- 批准号:
1402706 - 财政年份:2014
- 资助金额:
$ 69.98万 - 项目类别:
Standard Grant
MRI: Acquisition of a High-Pressure Freezing System for Cryo-Electron Microscopy
MRI:获取用于冷冻电子显微镜的高压冷冻系统
- 批准号:
1428296 - 财政年份:2014
- 资助金额:
$ 69.98万 - 项目类别:
Standard Grant
Conference on Bacteria-Material Interactions
细菌-材料相互作用会议
- 批准号:
1301740 - 财政年份:2013
- 资助金额:
$ 69.98万 - 项目类别:
Standard Grant
I-Corps: Gel-Tethered Molecular Beacons
I-Corps:凝胶束缚分子信标
- 批准号:
1262903 - 财政年份:2012
- 资助金额:
$ 69.98万 - 项目类别:
Standard Grant
NIRT: Self-Assembled Nanohydrogels for Differential Cell Adhesion and Infection Control
NIRT:用于差异细胞粘附和感染控制的自组装纳米水凝胶
- 批准号:
0708379 - 财政年份:2007
- 资助金额:
$ 69.98万 - 项目类别:
Standard Grant
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