NIRT: Self-Assembled Nanohydrogels for Differential Cell Adhesion and Infection Control

NIRT：用于差异细胞粘附和感染控制的自组装纳米水凝胶

• 批准号: 0708379
• 负责人: Matthew Libera
• 金额: $ 100万
• 依托单位: Stevens Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2013-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0708379&HistoricalAwards=false
• 关键词: NIRT; Self; Assembled; Nanohydrogels; Differential

This proposal was received in response to the Active Nanostructures and Nanosystems initiative, NSF 06-595, category NIRT. CBET-0708379Libera, Matthew R.Stevens Institute of TechnologyTitle:NIRT: Self-Assembled Nanohydrogels for Differential Cell Adhesion and Infection ControlThis project centers on the design and self-assembly of nanohydrogels that will either be adhesive to cells or repulsive to cells.The special adhesive feature of the biomaterial relies on the detailed spatial composition of cell-adhesive and cell-repulsive nano sized hydrogels. The investigators are utilizing the well-documented differential in binding of eukaryotic cells versus bacteria. They are utilizing a very straight forward and creative mechanism for creating these controllable cell adherent surfaces. Finally, the successful completion of the project will lead to a major advancement in biomaterial. Such material will find wide surgical application.

该提案是针对主动纳米结构和纳米系统倡议，NSF 06-595，类别NIRT收到的。 CBET-0708379LIBERA，MATTHEW R.STEVENS技术研究所：NIRT：用于差分细胞粘附和感染控制的自组装纳米水凝胶和感染控制的纳米水凝胶的设计和自组件，这些纳米水直凝胶将与细胞或依赖性的依赖性相结合。细胞粘附和细胞抑制性纳米大小的水凝胶。 研究人员正在利用有据可查的差异来结合真核细胞与细菌的结合。他们利用一种非常直接和创造性的机制来创建这些可控的细胞粘附表面。最后，该项目的成功完成将导致生物材料的重大进步。此类材料将发现广泛的手术应用。