The 5th Stevens Conference on Bacteria-Material Interactions

第五届史蒂文斯细菌-材料相互作用会议

• 批准号: 1907604
• 负责人: Matthew Libera
• 金额: $ 0.79万
• 依托单位: Stevens Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2020-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1907604&HistoricalAwards=false
• 关键词: 5th; Stevens; Conference; Bacteria; Material

Nontechnical abstractThis project supports a research conference called the Stevens Conference on Bacteria-Material Interactions. This two-day Conference will be held in June 2019 on the campus of the Stevens Institute of Technology in Hoboken, New Jersey, very close to New York City. The 2019 Conference is the 5th in a series of Conferences that started in 2011, and this series is recognized as a key national and international venue for pushing the limits of scientific understanding about how bacteria interact with man-made surfaces. Bacterial-material interactions is an important scientific subject because of the devastating impact that bacterial colonization of man-made biomedical devices, such as hip or knee implants, can have on patient outcomes. Such infection can lead to long and painful hospital stays that can culminate in compromised function, chronic disease, or death. This project is helping graduate research students, post-doctoral research fellows, and early-career Faculty members to attend the conference and develop their expertise and professional careers in this important emerging field.Technical abstractUnderstanding the fundamental science underlying how bacteria interact with biomaterials surfaces and how those surfaces can be modified to resist colonization is at the heart of an emerging new sub-field within Biomaterials Science and Engineering, namely, infection-resisting biomaterials. While the idea of creating antifouling surfaces that resist bacterial colonization has been known for decades, antifouling surfaces are not useful in many key clinical applications, because their ability to resist bacterial colonization also prevents the desirable tissue interactions associated with healing. The scientific challenge thus focuses on creating surfaces that are differentially interactive and can simultaneously promote favorable tissue-cell interactions while also inhibiting bacterial interactions. To deeply explore this subject, the 5th Stevens Conference is focused on the scientific fundamentals addressing: (i) antimicrobials and antimicrobial action; (ii) infection models; (iii) bacterial response to a surface; and (iv) surface modification. The Conference features fifteen invited lectures by recognized topical experts from around the world. Significantly, the Conference also involves the perspectives of highly expert clinicians who can help keep fundamental scientific advances aligned with critical societal needs. This project is providing partial financial support that enables graduate research students, post-doctoral research fellows, and early-career Faculty members to attend the Conference. These young scientists and engineers consequently have the opportunity to present their own research findings, network with and learn from internationally recognized experts in the field, as well as develop their professional careers to help impact this important emerging field in the future.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

非技术摘要这个项目支持一个名为史蒂文斯细菌-材料相互作用会议的研究会议。本次为期两天的会议将于2019年6月在距离纽约市非常近的新泽西州霍博肯的史蒂文斯理工学院校园内举行。2019年会议是2011年开始的一系列会议中的第5次，这一系列会议被公认为推动对细菌与人造表面相互作用的科学理解的极限的关键国内和国际场所。细菌与材料的相互作用是一个重要的科学课题，因为人工生物医学设备(如髋关节或膝盖植入物)的细菌定植可能会对患者的预后产生毁灭性的影响。这种感染可能导致长期痛苦的住院治疗，最终可能导致功能受损、慢性病或死亡。这个项目正在帮助研究生、博士后研究员和职业生涯早期的教师成员参加会议，并在这个重要的新兴领域发展他们的专业知识和职业生涯。技术摘要了解细菌如何与生物材料表面相互作用以及如何对这些表面进行修饰以抵抗定植是生物材料科学与工程中一个新兴的新子领域，即抗感染生物材料的核心。虽然创建抗细菌定植的防污表面的想法几十年来一直是已知的，但防污表面在许多关键的临床应用中并不有用，因为它们抵抗细菌定植的能力也阻止了与愈合相关的理想的组织相互作用。因此，科学挑战的重点是创造具有差异性相互作用的表面，同时可以促进有利的组织-细胞相互作用，同时也抑制细菌相互作用。为了深入探讨这一主题，第五届史蒂文斯会议侧重于科学基础，涉及：(1)抗菌剂和抗菌作用；(2)感染模式；(3)细菌对表面的反应；以及(4)表面修饰。该会议由来自世界各地的知名专题专家作了15场特邀讲座。值得注意的是，会议还涉及高度专业的临床医生的观点，他们可以帮助保持基本的科学进步与关键的社会需求保持一致。该项目提供部分财政支持，使研究生、博士后研究员和职业生涯早期的教师成员能够参加会议。因此，这些年轻的科学家和工程师有机会展示他们自己的研究成果，与该领域的国际公认专家建立网络并向其学习，并发展他们的职业生涯，以帮助在未来影响这一重要的新兴领域。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。