CAREER: A new Telemedicine Platform using Incoherent Lensfree Cell Holography and Microscopy On a Chip

事业：使用非相干无透镜细胞全息术和芯片显微镜的新型远程医疗平台

• 批准号: 0954482
• 负责人: Aydogan Ozcan
• 金额: $ 40万
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0954482&HistoricalAwards=false
• 关键词: CAREER; new; Telemedicine; Platform; using

0954482OzcanThe recent revolutionary progress in digital technologies together with novel image reconstruction algorithms and theories can fundamentally transform the way that we conduct cell microscopy, cytometry and medical diagnostics. With this vision, this proposal makes a systematic effort to highlight this timely opportunity to revolutionize cell microscopy by making it free of any lenses, lasers or other bulky optical components with a much simpler, compact and cost-effective imaging architecture especially suitable for telemedicine needs and requirements. Through incoherent lensfree cell holography & on-chip microscopy platform of this proposal (i.e., LUCAS), the PI proposes to compensate in the digital domain for the lack of complexity of optical components by recording individual phase & amplitude holograms of various cell types. These cell holograms also yield accurate reconstruction of microscopic images featuring sub-cellular resolution over a very large field of view (FOV) even at cell densities reaching up to ~0.4 Million cells/ìL. Merging cost-effective and compact LUCAS imagers with the state-of-the-art cell-phone technology will create numerous opportunities for telemedicine to improve health care especially in the developing world where medical facilities and infrastructure are extremely limited.

数字技术的最新革命性进展以及新的图像重建算法和理论可以从根本上改变我们进行细胞显微镜、细胞测量和医疗诊断的方式。在这一愿景下，该提案系统地努力突出这一及时的机会，使其摆脱任何透镜、激光或其他笨重的光学组件，具有更简单、紧凑和经济高效的成像体系结构，特别适合远程医疗的需求和要求。通过本方案的非相干无透镜细胞全息术和芯片上显微镜平台(即Lucas)，PI提出通过记录各种细胞类型的单独的相位和幅度全息图，在数字域中补偿光学元件的复杂性的缺乏。这些细胞全息图还可以在非常大的视场(FOV)内精确重建具有亚细胞分辨率的显微图像，即使在细胞密度高达~40万个/微升的情况下也是如此。将经济高效且紧凑的Lucas成像仪与最先进的手机技术相结合，将为远程医疗创造大量改善医疗保健的机会，特别是在医疗设施和基础设施极其有限的发展中国家。