BME: High-resolution Microscopy based on Resonant Nano-Arrays

提出的研究计划包括利用共振纳米结构阵列开发一种新型高分辨率显微镜。这种新型显微镜被称为纳米阵列显微镜（NAM），它可以将低数值孔径（NA）显微镜的空间分辨率提高5倍，而不会降低其大视场（FOV）。结果表明，在~5 mm2视场范围内，NAM可实现~500 nm的空间分辨率和200 mm2/min的快速图像采集速度。此外，所提出的NAM概念也可以扩展到光谱的中红外部分，在5-16微米的光谱波长区域提供~2微米的分辨率，其中包含许多生物分子的独特化学特征。该提案的总体目标是将显微镜的概念与纳米光子学和等离子体学相结合，以实现新的成像概念。

CBET-0754880, OzcanThe proposed research plan covers the development of a new form of high resolution microscope by using an array of resonant nanostructures. This novel microscopy modality, which is termed as NanoArray based Microscopy (NAM) can improve the spatial resolution of a low numerical aperture (NA) microscope by e.g., 5 fold without degrading its large field-of-view (FOV). As a result, NAM can achieve a spatial resolution of ~500 nm over ~5 mm2 FOV, and a fast image acquisition speed of 200 mm2/min. Furthermore, the proposed NAM concept can also be extended to the mid-infrared part of the spectrum, providing a resolution of ~2 microns in the spectral wavelength region of 5-16 microns, which contains unique chemical signatures of many biomolecules. The broad goal of this proposal is to merge the concepts of microscopywith nanophotonics and plasmonics to enable new imaging concepts.