MRI: Acquisition of a 500 MHz Nuclear Magnetic Resonance Spectrometer for Undergraduate Research and Training

MRI：采购 500 MHz 核磁共振波谱仪用于本科生研究和培训

• 批准号: 1919596
• 负责人: Gregory Springsteen
• 金额: $ 48.5万
• 依托单位: Furman University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1919596&HistoricalAwards=false
• 关键词: MRI; Acquisition; 500; MHz; Nuclear

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Professor Gregory Springsteen from Furman University and colleagues Timothy Hanks and Mary Daub are acquiring a 500 MHz NMR spectrometer equipped with an automatic sample changer. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The NMR studies improve understanding of synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument is an integral part of teaching as well as research. This broadly accessible instrumentation strengthens the regional NMR analytical infrastructure and help advance the scientific careers of many undergraduate students from this institution, as well as those from neighboring Historically Black Colleges and Universities (HBCUs), community colleges and first generation-serving institutions. Industrial collaborations are also in place.The award is aimed at enhancing research and education at all levels. It especially aids exploration of prebiotic reactions leading to new knowledge on the origin of biological metabolism and for the development of sensors that could be useful for drug-delivery vesicles built from self-assembled fatty acids. The spectrometer is used to characterize synthesized compounds using oxidative photocycloaddition reactions that may have potential use as antifungal and antibiotic compounds and it is also employed to elucidate structure-activity relationships in the hibiscone family of natural products. The new instrumentation is being utilized for studies on solar energy conversion to be stored as chemical energy and for the study of immobilized surface luminescent materials, and for the study of the DNA-binding proteins having a motif known as AT hook.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器项目和化学研究仪器项目支持。福尔曼大学的格雷戈里·斯普林斯汀教授及其同事蒂莫西·汉克斯和玛丽·达布正在购买一台配备了自动换样器的500 MHz核磁共振光谱仪。总的来说，核磁共振波谱是化学家用来阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体中相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。核磁共振研究提高了对合成有机/无机化学、材料化学和生物化学的理解。该仪器是教学和研究不可分割的一部分。这种可广泛使用的仪器加强了区域核磁共振分析基础设施，并有助于推进该机构许多本科生的科学生涯，以及来自邻近历史上的黑人学院和大学(HBCU)、社区学院和第一代服务机构的学生。该奖项旨在加强各个层面的研究和教育。它尤其有助于探索益生反应，从而获得关于生物新陈代谢起源的新知识，并有助于开发可用于由自组装脂肪酸构建的药物输送囊泡的传感器。该光谱仪被用来表征通过氧化光环加成反应合成的化合物，这些反应可能作为抗真菌和抗生素化合物的潜在用途，它也被用于阐明硫比酮类天然产物的结构-活性关系。新的仪器正被用于太阳能转换的研究，以化学能量的形式储存，并用于固定化表面发光材料的研究，以及具有AT钩状结构的DNA结合蛋白的研究。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。