MRI: Acquisition of a 500 MHz Nuclear Magnetic Resonance Spectrometer for Undergraduate Research and Training

该奖项由主要研究仪器和化学研究仪器计划支持。来自弗曼大学的格雷戈里·斯普林斯汀教授和同事蒂莫西·汉克斯和玛丽·道布正在购买一台配备自动进样器的500 MHz NMR光谱仪。一般来说，核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。NMR研究提高了对合成有机/无机化学，材料化学和生物化学的理解。该仪器是教学和研究的一个组成部分。这种广泛使用的仪器加强了区域NMR分析基础设施，并有助于推进该机构的许多本科生的科学事业，以及邻近的历史黑人学院和大学（HBCU），社区学院和第一代服务机构的科学事业。该奖项旨在加强各级的研究和教育。它特别有助于探索益生元反应，从而获得关于生物代谢起源的新知识，并用于开发可用于自组装脂肪酸构建的药物递送囊泡的传感器。该光谱仪用于表征合成的化合物，使用氧化光环加成反应，可能有潜在的用途作为抗真菌和抗生素化合物，它也被用来阐明结构-活性关系的木槿酮家族的天然产物。新仪器被用于研究太阳能转换为化学能储存，用于研究固定表面发光材料，用于研究具有AT钩基序的DNA结合蛋白质。该奖项反映了NSF的法定使命，通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Professor Gregory Springsteen from Furman University and colleagues Timothy Hanks and Mary Daub are acquiring a 500 MHz NMR spectrometer equipped with an automatic sample changer. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The NMR studies improve understanding of synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument is an integral part of teaching as well as research. This broadly accessible instrumentation strengthens the regional NMR analytical infrastructure and help advance the scientific careers of many undergraduate students from this institution, as well as those from neighboring Historically Black Colleges and Universities (HBCUs), community colleges and first generation-serving institutions. Industrial collaborations are also in place.The award is aimed at enhancing research and education at all levels. It especially aids exploration of prebiotic reactions leading to new knowledge on the origin of biological metabolism and for the development of sensors that could be useful for drug-delivery vesicles built from self-assembled fatty acids. The spectrometer is used to characterize synthesized compounds using oxidative photocycloaddition reactions that may have potential use as antifungal and antibiotic compounds and it is also employed to elucidate structure-activity relationships in the hibiscone family of natural products. The new instrumentation is being utilized for studies on solar energy conversion to be stored as chemical energy and for the study of immobilized surface luminescent materials, and for the study of the DNA-binding proteins having a motif known as AT hook.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.