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RUI: Microdroplet Interface Chemistry-Fundamental Studies of Self-Assembled Structures at the Liquid/Liquid Interface

RUI：微滴界面化学-液/液界面自组装结构的基础研究

基本信息

批准号：
1212967
负责人：
Sunghee Lee
金额：
$ 25万
依托单位：
IONA UNIVERSITY
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-01 至 2016-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1212967&HistoricalAwards=false
关键词：
RUI Microdroplet Interface Chemistry Fundamental

项目摘要

The Macromolecular, Supramolecular and Nanochemistry (MSN) Program of the Division of Chemistry (CHE) at the National Science Foundation supports the work of Professor Sunghee Lee at Iona College, concerning how supramolecular aggregates direct the crystallization of substances at a liquid-liquid interface. The research includes: (1) investigating the effect of surfactant monolayer structure upon crystallization by employing polymorphic organic crystal systems as reporters for subtle changes in monolayer structure; (2) studying the mechanism by which lipid bilayers in mesophases promote the crystallization of important protein targets through establishment of the droplet interface bilayer as a model; and (3) determining the nature and extent of interaction of ions with bilayers using the droplet interface bilayer model.The research will enhance the body of empirical and systematic knowledge regarding arrangement of molecules which preferentially reside at the liquid-liquid interface. The understanding of molecular assemblies at the liquid-liquid interface will be an important contribution to fields which rely on these structures, such as biomimetic materials synthesis, electronics, diagnostics, drug delivery, and the plastic and pharmaceutical industries. Undergraduate students will perform research, co-author the relevant publications, and present their findings at national meetings. Thus, the research will impact the future career pathways in science available to numerous undergraduates, through enhanced availability and depth of research training at Iona College, a predominantly undergraduate institution.

国家科学基金会化学部（CHE）的大分子，超分子和纳米化学（MSN）计划支持艾奥纳学院的Sunghee Lee教授的工作，关于超分子聚集体如何在液-液界面指导物质的结晶。研究内容包括：（1）以多晶型有机晶体系统为报告分子，研究表面活性剂单分子层结构对结晶的影响;（2）以液滴界面双分子层为模型，研究中间相脂质双分子层促进重要蛋白质靶点结晶的机理;（3）利用液滴界面双层模型确定离子与双层膜相互作用的性质和程度，这一研究将丰富有关优先驻留在液-液界面的分子排列的经验和系统知识。对液-液界面分子组装的理解将对依赖于这些结构的领域做出重要贡献，例如仿生材料合成，电子学，诊断学，药物输送以及塑料和制药工业。本科生将进行研究，共同撰写相关出版物，并在国家会议上展示他们的发现。因此，通过提高以本科生为主的艾奥纳学院研究培训的可用性和深度，这项研究将影响众多本科生未来的科学职业道路。