MRI: Acquisition of Confocal Raman Microscope for the Enhancement of Research and Education at Iona College

MRI：购买共焦拉曼显微镜以加强爱奥纳学院的研究和教育

• 批准号: 1427705
• 负责人: Sunghee Lee
• 金额: $ 18.42万
• 依托单位: IONA UNIVERSITY
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1427705&HistoricalAwards=false
• 关键词: MRI; Acquisition; Confocal; Raman; Microscope

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program, Iona College will acquire an inverted confocal Raman microscope. A microscope, which combines a Raman spectrometer with a confocal optical microscope, provides qualitative and quantitative vibrational information for structural and molecular analysis of materials at both the microscopic and bulk level. By scanning across a sample with high spatial resolution it provides analytical information on a wide range of samples, including biological matrices. The acquisition will provide training to undergraduate students in the use of this modern analytical tool. It will strengthen research opportunities for students in STEP and CSTEP (Collegiate STEP) programs funded by New York State that encourage underrepresented groups and outreach activities to high school teachers and students.The acquistion is aimed at enhancing research and education at all levels, especially in areas such as (a) studying in-situ microdroplet crystallization; (b) designing nanoparticle intracellular probes and small-molecule delivery/detection devices and probing cellular uptake of the nanocomplexes in situ for synthesis of drug delivery vehicles; (c) elucidating fundamental biotoxicity mechanisms of type-2 alkenes via examination of intracellular tracking of various molecular indicators for prediction of the toxicity of environmental chemicals; and (d) characterizing copper nitrosyls compounds and mechanisms of nitrosylations and denitrosylations to develop denitrosylations and catalysis for environmental/biological applications.

在重大研究仪器计划(MRI)的这一奖项和化学研究仪器计划的支持下，IONA学院将获得一台倒置共焦拉曼显微镜。显微镜结合了拉曼光谱仪和共焦光学显微镜，为材料的微观和整体水平的结构和分子分析提供了定性和定量的振动信息。通过以高空间分辨率扫描样品，它提供了关于包括生物基质在内的各种样品的分析信息。此次收购将为本科生提供使用这一现代分析工具的培训。它将加强由纽约州资助的STEP和CSTEP(大学步骤)项目的研究机会，这些项目鼓励代表性不足的团体，并向高中教师和学生开展外联活动。该成果旨在加强各级的研究和教育，特别是在以下领域：(A)研究原位微滴结晶；(B)设计纳米颗粒细胞内探针和小分子输送/检测装置，并探测纳米复合体的细胞原位摄取，以合成药物输送载体；(C)通过检查预测环境化学品毒性的各种分子指标的细胞内跟踪，阐明2型烯烃的基本生物毒性机理；以及(D)表征亚硝基铜化合物以及亚硝化和反硝化的机理，以开发用于环境/生物应用的反硝化和催化。

项目成果

Ibuprofen and the Phosphatidylcholine Bilayer: Membrane Water Permeability in the Presence and Absence of Cholesterol

布洛芬和磷脂酰胆碱双层：存在和不存在胆固醇时的膜水渗透性

• DOI: 10.1021/acs.langmuir.0c03638
• 发表时间: 2021
• 期刊: Langmuir
• 影响因子: 3.9
• 作者: Wood, Megan;Morales, Michael;Miller, Elizabeth;Braziel, Samuel;Giancaspro, Joseph;Scollan, Patrick;Rosario, Juan;Gayapa, Alyssa;Krmic, Michael;Lee, Sunghee
• 通讯作者: Lee, Sunghee

Trans-Resveratrol Decreases Membrane Water Permeability: A Study of Cholesterol-Dependent Interactions

• DOI: 10.1007/s00232-022-00250-0
• 发表时间: 2022-06-24
• 期刊: JOURNAL OF MEMBRANE BIOLOGY
• 影响因子: 2.4
• 作者: Ceja-Vega, Jasmin;Perez, Escarlin;Lee, Sunghee
• 通讯作者: Lee, Sunghee

Differential Effects of Soy Isoflavones on the Biophysical Properties of Model Membranes

• DOI: 10.1021/acs.jpcb.3c08390
• 发表时间: 2024-02-28
• 期刊: JOURNAL OF PHYSICAL CHEMISTRY B
• 影响因子: 3.3
• 作者: Gudyka，Jamie;Ceja-Vega，Jasmin;Lee，Sunghee
• 通讯作者: Lee，Sunghee