RUI: Biomimetic Self-Assembly: Physical State and the Barrier Function to Water Permeation

RUI：仿生自组装：物理状态和水渗透的屏障功能

• 批准号: 2002900
• 负责人: Sunghee Lee
• 金额: $ 30万
• 依托单位: IONA UNIVERSITY
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2002900&HistoricalAwards=false
• 关键词: RUI; Biomimetic; Self; Assembly; Physical

The Macromolecular, Supramolecular, and Nanochemistry Program in the Chemistry Division at the National Science Foundation supports Professor Sunghee Lee of Iona College to study how supramolecular self-assemblies at micrometer-sized liquid-liquid interfaces control the passage of water. The study promotes our understanding of how living cells can selectively retain and release their water content. Such water controlling mechanisms are essential to understanding not only life's origins but also the functions of major organs such as the skin and kidneys. More broadly, the project has a potential to contribute to human health and clean water applications that rely on the retention and elimination of water and waste. The research enables training for a large number of undergraduate research participants in the project. The research team further broadens the impact of their work by developing outreach seminars and science symposia for high school students and teachers that inspire and engage students to enter science, technology, engineering, and mathematics (STEM) fields, particularly those from underrepresented groups. Professor Lee and her students travel to the University of Tokyo in Japan to conduct experiments on high-throughput device fabrication obtaining a global perspective on science. This research is focused on elucidating how supramolecular self-assemblies at micron-sized liquid-liquid interfaces can serve as controllable barriers for the passage of water. The team of researchers, Professor Lee and undergraduate students at Iona College, will investigate the directionality of the water movement, and balance between permeability and stability in protocell models through experimental activities strategized to determine the water permeability parameters and energy of activation for osmotic flow, electrical properties of capacitance and leakage current, diffusional water permeability, and adhesion energy. Upon successful completion, this research could provide fundamental insights into how lipid asymmetry plays a role in organismal water homeostasis, and the balance between stability and permeability in prebiotic cellular models.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

美国国家科学基金会化学部的大分子、超分子和纳米化学项目支持爱奥娜学院的Sunghee Lee教授研究微米级液-液界面上的超分子自组装如何控制水的通过。这项研究促进了我们对活细胞如何选择性地保留和释放水分的理解。这样的水控制机制不仅对了解生命的起源，而且对了解皮肤和肾脏等主要器官的功能至关重要。更广泛地说，该项目有可能促进依赖于保留和消除水和废物的人类健康和清洁用水的应用。该研究为大量本科生研究参与者提供了培训。研究小组通过为高中学生和教师举办外展研讨会和科学专题讨论会，激励和吸引学生进入科学、技术、工程和数学（STEM）领域，特别是那些来自代表性不足群体的学生，进一步扩大了他们工作的影响。李教授和她的学生前往日本东京大学进行高通量器件制造实验，以获得全球科学视角。本研究的重点是阐明微米级液-液界面上的超分子自组装如何作为水通过的可控屏障。研究团队，李教授和Iona学院的本科生，将通过实验活动来研究水运动的方向性，以及原始细胞模型中渗透性和稳定性之间的平衡，以确定水的渗透性参数和渗透流动的激活能量，电容和泄漏电流的电学性质，扩散水的渗透性和粘附能。一旦成功完成，这项研究将为了解脂质不对称如何在生物元细胞模型中的有机水稳态以及稳定性和渗透性之间的平衡中发挥作用提供基础见解。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Ibuprofen and the Phosphatidylcholine Bilayer: Membrane Water Permeability in the Presence and Absence of Cholesterol

布洛芬和磷脂酰胆碱双层：存在和不存在胆固醇时的膜水渗透性

• DOI: 10.1021/acs.langmuir.0c03638
• 发表时间: 2021
• 期刊: Langmuir
• 影响因子: 3.9
• 作者: Wood, Megan;Morales, Michael;Miller, Elizabeth;Braziel, Samuel;Giancaspro, Joseph;Scollan, Patrick;Rosario, Juan;Gayapa, Alyssa;Krmic, Michael;Lee, Sunghee
• 通讯作者: Lee, Sunghee

Increasing Retention of STEM Students with Financial Need via the NSF S-STEM DESIRE Scholarship Program

通过 NSF S-STEM DESIRE 奖学金计划提高有经济需要的 STEM 学生的保留率

• 发表时间: 2021
• 期刊: Journal of STEM education
• 作者: Wright BM;Zaromatidis K
• 通讯作者: Zaromatidis K

Trans-Resveratrol Decreases Membrane Water Permeability: A Study of Cholesterol-Dependent Interactions

• DOI: 10.1007/s00232-022-00250-0
• 发表时间: 2022-06-24
• 期刊: JOURNAL OF MEMBRANE BIOLOGY
• 影响因子: 2.4
• 作者: Ceja-Vega, Jasmin;Perez, Escarlin;Lee, Sunghee
• 通讯作者: Lee, Sunghee

Differential Interaction of Cannabidiol with Biomembranes Dependent on Cholesterol Concentration

大麻二酚与生物膜的差异相互作用取决于胆固醇浓度

• DOI: 10.1021/acschemneuro.2c00040
• 发表时间: 2022
• 期刊: ACS Chemical Neuroscience
• 影响因子: 5
• 作者: Perez, Escarlin;Ceja-Vega, Jasmin;Krmic, Michael;Gamez Hernandez, Alondra;Gudyka, Jamie;Porteus, Riley;Lee, Sunghee
• 通讯作者: Lee, Sunghee

Differential Effects of Soy Isoflavones on the Biophysical Properties of Model Membranes

• DOI: 10.1021/acs.jpcb.3c08390
• 发表时间: 2024-02-28
• 期刊: JOURNAL OF PHYSICAL CHEMISTRY B
• 影响因子: 3.3
• 作者: Gudyka，Jamie;Ceja-Vega，Jasmin;Lee，Sunghee
• 通讯作者: Lee，Sunghee