ERP and fMRI of emotion and cognition in psychopathy

精神病患者情绪和认知的 ERP 和 fMRI

• 批准号: 7354813
• 负责人: KENT A KIEHL
• 金额: $ 32.11万
• 依托单位: THE MIND RESEARCH NETWORK
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-12-12 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7354813
• 关键词: Address; Affect; Affective; Alcohols; Amygdaloid structure; Anterior; Architecture; Behavioral; Bilateral; Brain; Brain Injuries; Brain region; Caucasians; Caucasoid Race; Characteristics; Cognition; Communities; Data; Dependence; Disease; Disruption; Drug Addiction; Economics; Emotional; Emotions; Event-Related Potentials; Female; Forensic Medicine; Functional Magnetic Resonance Imaging; Functional disorder; Gender; General Population; Hares; Hippocampus (Brain); Image; Individual; Left; Life Style; Localized; Maps; Mental disorders; Mind; Modeling; Monitor; Neuroanatomy; Neurocognitive; Patients; Performance; Personality Disorders; Platelet Factor 4; Population; Population Heterogeneity; Prevalence; Principles of law and justice; Process; Psychometrics; Psychopath; Purpose; Race; Recording of previous events; Recruitment Activity; Relative (related person); Research Personnel; Resolution; Sampling; Schizophrenia; Score; Severities; Solutions; Stimulus; Structure; Substance Addiction; Superior temporal gyrus; Symptoms; System; Techniques; Testing; Work; anti social; base; cognitive neuroscience; cost; criminal offending; criminal psychopathy; frontal lobe; hemodynamics; lexical; low socioeconomic status; male; offender; probation; psychopathic personality; relating to nervous system; response; socioeconomics; stimulus processing

DESCRIPTION (provided by applicant): Psychopathy is a personality disorder comprised of a constellation of interpersonal, affective and behavioral characteristics. Individuals with psychopathy are responsible for a disproportionate amount of civil disruption, both criminal and noncriminal. The societal cost of psychopathy, including fiscal and emotional components, rivals those of other major mental illnesses of similar prevalence (~1% general population). However, relative to other major disorders (e.g., schizophrenia), little is known about the neurocognitive systems implicated in psychopathy. Recent small scale electrophysiological and hemodynamic imaging studies done by the primary investigator have shown that criminal psychopathy is associated with functional abnormalities in the paralimbic system during performance of affective, error-monitoring, and salient stimulus (e.g., oddball) processing tasks. The primary paralimbic structures that appear to be implicated include the amygdala, orbital frontal cortex, anterior superior temporal gyrus, rostral and caudal anterior cingulate, and posterior cingulate. The purpose of the present proposal is to test the paralimbic hypothesis of psychopathy in samples drawn from community based populations of ethically diverse males and females from varied socio-economic backgrounds. High temporal resolution electrophysiological techniques and high spatial resolution hemodynamic imaging will be used to map the functional neural architecture associated with affective, error-monitoring, and salient stimulus processing tasks in groups stratified by psychopathy scores. The ultimate aim of the proposed project is to obtain a more complete understanding of the brain systems implicated in psychopathy, and secondarily, to begin to understand how brain function relates to psychopathic symptomology. At the conclusion of the study, data will be available to characterize dysfunctional neuroanatomy in psychopaths not drawn exclusively from incarcerated samples. The data also will permit an examination of psychopathy-specific paralimbic brain function abnormalities along gender and socioeconomic lines, exploration of how brain function abnormalities relate to psychopathy symptom subtypes, and will provide data on the inter-relationship of functional brain abnormalities in psychopathy and alcohol and substance disorders.

描述（由申请人提供）：精神病是一种人格障碍，包括人际关系，情感和行为特征。患有精神病的人对不成比例的民事破坏负有责任，包括刑事和非刑事。精神病的社会成本，包括财政和情感因素，与其他类似患病率的主要精神疾病（约占总人口的1%）相媲美。然而，相对于其他主要疾病（例如，精神分裂症），很少有人知道涉及精神病的神经认知系统。主要研究者最近进行的小规模电生理和血液动力学成像研究表明，犯罪性精神病与情感、错误监测和显著刺激（例如，古怪的）处理任务。与此相关的主要大脑边缘系统结构包括杏仁核、眶额皮质、前上级颞回、前扣带回的头侧和尾侧以及后扣带回。本建议的目的是测试从不同的社会经济背景的道德不同的男性和女性的社区为基础的人口样本的精神病的边缘假设。高时间分辨率的电生理技术和高空间分辨率的血流动力学成像将被用来映射与情感，错误监测，和显着的刺激处理任务的组分层的精神病评分的功能神经架构。本计画的最终目的是为了更完整地了解与精神病态有关的脑系统，其次是开始了解脑功能与精神病态的关系。在研究结束时，数据将可用于描述精神病患者的功能障碍神经解剖学，而不仅仅是从监禁样本中提取。这些数据还将允许检查精神病特异性边缘脑功能异常沿着性别和社会经济线，探索脑功能异常如何与精神病症状亚型相关，并将提供关于精神病和酒精和物质障碍的功能性脑异常的相互关系的数据。

项目成果

Abnormal fronto-limbic engagement in incarcerated stimulant users during moral processing.

被监禁的兴奋剂使用者在道德处理过程中额叶边缘的异常参与。

• DOI: 10.1007/s00213-016-4344-4
• 发表时间: 2016
• 期刊: Psychopharmacology
• 影响因子: 3.4
• 作者: Fede,SamanthaJ;Harenski,CarlaL;SchaichBorg,Jana;Sinnott-Armstrong,Walter;Rao,Vikram;Caldwell,BrendanM;Nyalakanti,PrashanthK;Koenigs,MichaelR;Decety,Jean;Calhoun,VinceD;Kiehl,KentA
• 通讯作者: Kiehl,KentA

Infection, incest, and iniquity: investigating the neural correlates of disgust and morality.

• DOI: 10.1162/jocn.2008.20109
• 发表时间: 2008-09
• 期刊: Journal of cognitive neuroscience
• 影响因子: 3.2
• 作者: Schaich Borg J;Lieberman D;Kiehl KA
• 通讯作者: Kiehl KA

Neuroprediction, Violence, and the Law: Setting the Stage.

神经预测、暴力和法律：奠定基础。

• DOI: 10.1007/s12152-010-9095-z
• 发表时间: 2012
• 期刊: Neuroethics
• 影响因子: 1.4
• 作者: Nadelhoffer,Thomas;Bibas,Stephanos;Grafton,Scott;Kiehl,KentA;Mansfield,Andrew;Sinnott-Armstrong,Walter;Gazzaniga,Michael
• 通讯作者: Gazzaniga,Michael

Impulsive-antisocial dimension of psychopathy linked to enlargement and abnormal functional connectivity of the striatum.

• DOI: 10.1016/j.bpsc.2016.07.004
• 发表时间: 2017-03
• 期刊: Biological psychiatry. Cognitive neuroscience and neuroimaging
• 作者: Korponay C;Pujara M;Deming P;Philippi C;Decety J;Kosson DS;Kiehl KA;Koenigs M
• 通讯作者: Koenigs M

Reactive aggression in psychopathy and the role of frustration: susceptibility, experience, and control.

精神病中的反应性攻击和挫折的作用：敏感性、经验和控制。

• DOI: 10.1348/000712609x471067
• 发表时间: 2010
• 期刊: British journal of psychology (London, England : 1953)
• 作者: Harenski,CarlaL;Kiehl,KentA
• 通讯作者: Kiehl,KentA