权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Fluid-structure interaction with multi-layered structures: a new class of partitioned schemes

多层结构的流固耦合：一类新的分区方案

基本信息

批准号：
1318763
负责人：
Suncica Canic
金额：
$ 28.09万
依托单位：
University of Houston
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2013
资助国家：
美国
起止时间：
2013-08-15 至 2019-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1318763&HistoricalAwards=false
关键词：
Fluid structure interaction multi layered

项目摘要

Fluid-structure interaction (FSI) problems arise in many applications. They include multi-physics problems in engineering such as aeroelasticity and propeller turbines, as well as biofluidic application such as self-propulsion organisms, fluid-cell interactions, and the interaction between blood flow and cardiovascular tissue. A comprehensive study of these problems remains to be a challenge due to their strong nonlinearity and multi-physics nature. To make things worse, in many biological applications the structure is composed of several layers, each with different mechanical characteristics. This is, for example, the case with arterial walls. A FSI solver that simulates the interaction between an incompressible, viscous fluid and a multi-layered structure would be an indispensable tool for the computational studies of this class of problems. To date, there are no such FSI solvers for hemodynamics, and the work proposed here makes a first step in this direction. The investigators are developing a set of stable loosely-coupled partitioned schemes for solving a class of nonlinear moving boundary, fluid-multi-structure interaction problems. The proposed schemes are based on a novel implementation of the Lie operator splitting, which is designed in such a way that the energy of the discretized problem mimics the energy of the continuous problem. The proposed program opens up a new field within the area of FSI problems, bringing to light several new features that have not been studied before, such as the study of the regularizing effects of fluid-structure interfaces with mass. The proposed class of schemes will be implemented and optimized for high performance computing using an open source library of solvers called LifeV. This will make the products of this research accessible to a large set of users involving a broad range of applications.This is an exciting, novel study requiring the development of original mathematical and computational techniques motivated by important applications in cardiovascular flow. The investigators are developing a computational software that will, for the first time, capture the interaction between different layers of the human arterial walls as they interact with pulsating blood flow. This study is motivated by the most recent advances in ultrasound speckle tracking methods, which reveal that in high adrenaline situations, there is significant strain between different layers within arterial walls. It has been noted that the role of this phenomenon in the development of cardiovascular disease has not been explored yet. The computational models developed in this study will provide an indispensable tool for the study of the influence of this phenomenon on the physiology and pathophysiology of the human cardiovascular system. The results from this research will have impact across different scientific disciplines through an open source code, which will be freely available to users. The work proposed here promises to develop a strong partnership between the University of Houston, the University of Pittsburgh, Emory University, and the Texas Medical Center in Houston. The broader impacts will be further achieved through student education, mentoring of students and junior faculty, and organization of interdisciplinary conferences/workshops. Both investigators are women with a track record in education and mentoring women and minorities, and this practice will continue throughout this project.

流固耦合问题在很多应用中都会出现。它们包括工程中的多物理问题，如气动弹性和螺旋桨涡轮机，以及生物流体应用，如自推进生物体，流体细胞相互作用以及血流和心血管组织之间的相互作用。由于这些问题的强非线性和多物理场性质，对其进行全面的研究仍然是一个挑战。更糟糕的是，在许多生物应用中，这种结构由几层组成，每层都有不同的机械特性。例如，动脉壁就是这种情况。一个流固耦合求解器，模拟不可压缩，粘性流体和多层结构之间的相互作用将是这类问题的计算研究的一个不可缺少的工具。到目前为止，还没有这样的FSI求解器的血液动力学，这里提出的工作在这个方向上迈出了第一步。研究人员正在发展一套稳定的松耦合分区格式，用于求解一类非线性动边界、流体-多结构相互作用问题。所提出的方案是基于一种新的实现的李算子分裂，这是设计在这样一种方式，离散化问题的能量模仿的能量的连续问题。该计划开辟了一个新的领域内的FSI问题的区域内，带来了几个新的功能，没有被研究过，如流体结构界面与质量的正则化效果的研究。所提出的一类计划将被实施和优化的高性能计算使用一个开源库的求解器称为LifeV。这将使本研究的产品可供涉及广泛应用的大量用户使用。这是一项令人兴奋的新颖研究，需要开发原始的数学和计算技术，其动机是心血管血流中的重要应用。研究人员正在开发一种计算软件，该软件将首次捕获人体动脉壁不同层与脉动血流相互作用时的相互作用。这项研究的动机是超声斑点跟踪方法的最新进展，该方法揭示了在高肾上腺素的情况下，动脉壁内不同层之间存在显着的应变。已经注意到，这种现象在心血管疾病发展中的作用尚未被探索。本研究开发的计算模型将为研究这种现象对人类心血管系统生理和病理生理的影响提供不可或缺的工具。这项研究的结果将通过开源代码对不同的科学学科产生影响，这些代码将免费提供给用户。这里提出的工作承诺在休斯顿大学，匹兹堡大学，埃默里大学和休斯顿德克萨斯医学中心之间建立强有力的伙伴关系。更广泛的影响将进一步通过学生教育，学生和初级教师的辅导，跨学科会议/研讨会的组织实现。两名调查员都是在教育和指导妇女和少数民族方面有记录的妇女，这种做法将在整个项目中继续下去。