MRI: Acquisition of a 500 MHz Nuclear Magnetic Resonance Spectrometer for Research and Education

有了这个由化学研究仪器和设施（CRIF）计划共同资助的主要研究仪器计划的奖项，来自俄亥俄州大学的Tadeusz Malinski教授和同事Eric Masson，Stephen Bergmeier，Michael詹森和Jennifer Hines将获得500 MHz NMR光谱仪（11.7特斯拉磁体，54 mm孔径，带主动屏蔽）。新的光谱仪将具有梯度匀场，4-射频通道，可变温度单元和三个探针：用于观察1H同时解耦13 C和15 N核的反向三重共振微探针和多核宽带Fluorine Observe SmartProbe。该项目旨在加强各级的研究和教育，特别是在以下领域：（a）研究来自天然产品和合成制剂的高度复杂的大分子;（B）合成与医学有关的天然和非天然产品;（c）利用超分子化学研究葫芦脲族大环化合物的识别特性和应用;（d）利用超分子化学研究葫芦脲族大环化合物的识别特性和应用。（d）鉴定在较低场强下收集的光谱中具有大量重叠芳族质子的高度取代的聚吡啶-金属络合物;（e）使用顺磁NMR技术;（f）开发RNA靶向配体;和（g）一氧化氮（NO）信号通路。核磁共振（NMR）光谱是化学家用于阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些NMR研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将成为教学和研究的一个组成部分，并将影响大量的学生，包括一些来自阿巴拉契亚俄亥俄州地区和工业伙伴关系。合作将使来自格兰德河大学和肖尼州立大学的学生了解核磁共振仪器的科学能力。

With this award from the Major Research Instrumentation Program that is co-funded by the Chemistry Research Instrumentation and Facilities (CRIF) Program, Professor Tadeusz Malinski from Ohio University and colleagues Eric Masson, Stephen Bergmeier, Michael Jensen and Jennifer Hines will acquire a 500 MHz NMR spectrometer (11.7 Tesla magnet, 54 mm bore, with active shielding.) The new spectrometer would have gradient shimming, 4-radiofrequency channel, a variable temperature unit, and three probes: an inverse triple resonance microprobe for the observation of 1H while decoupling 13C and 15N nuclei and a multinuclear broadband Fluorine Observe SmartProbe. The project is aimed at enhancing research and education at all levels, especially in areas such as (a) study of highly complex macromolecules from natural products and from synthetic preparations; (b) synthesis of medicinally relevant natural and unnatural products; (c) study of recognition properties and applications of the Cucurbituril family of macrocycles using supramolecular chemistry; (d) identification of highly substituted polypyridine-metal complexes that have a large number of overlapping aromatic protons in spectra collected at lower field strength; (e) use of paramagnetic NMR techniques; (f) development of RNA-targeted ligands; and (g) nitric oxide (NO) signaling pathways.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research and will impact a large number of students including some from the Appalachian Ohio region and also industrial partnerships. Collaborations will expose students from the University of Rio Grande and Shawnee State to the scientific capabilities of NMR instrumentation.