Normobaric hypoxia training compared to ambient training on the course of the metabolic syndrom: influence on muscle function and structure

常压低氧训练与环境训练对代谢综合征病程的比较：对肌肉功能和结构的影响

• 批准号: 214218192
• 负责人: Professor Dr. Friedrich C. Luft
• 金额: --
• 依托单位: Experimental and Clinical Research Center (ECRC)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/214218192?language=en
• 关键词: Normobaric; hypoxia; training; compared; ambient

The patient numbers with metabolic syndrome and diabetes have doubled in the last decade. Data that physical exercise ameliorates the metabolic syndrome are convincing, although the mechanisms of the effect in man are not clear. Numerous endocrine or molecular mechanisms modified by physical exercise are known to be hypoxia-sensitive, i.e. by hypoxia-inducible factor-1 (HIF-1) regulation. Thus, relative hypoxia may link physical exercise and modification of endogenous metabolism. Medical communities seem ill equipped to address the primary issues involved. We have experience with normobaric “hypoxia chambers” and will now test a (physical exercise) training program, using state-ofthe- art assessments available nowhere else in Germany. We will compare hypoxia chamber, to ambient training, to test the notion that specific exercise conditions could regulate specific molecular pathways involved in the pathogenesis of the metabolic syndrome. Indeed, hypoxia chamber training could be superior to conventional training in terms of reducing cardiovascular risk factors or improving fitness. We will test overall metabolism-related effects with a metabolic chamber. We will test local metabolism with microdialysis during exercise routines, and we will perform fat and muscle biopsies to investigate tissue-related effects. We include experience from a broad-ranging spectrum. Our findings might improve understanding mechanisms linking physical exercise and endogenous metabolism. Furthermore, they could influence decision-making regarding non-pharmacological interventions.

患有代谢综合征和糖尿病的患者人数在过去十年中翻了一番。体育锻炼改善代谢综合征的数据是令人信服的，尽管其作用机制尚不清楚。已知通过体育锻炼改变的许多内分泌或分子机制是低氧敏感的，即通过低氧诱导因子-1（HIF-1）调节。因此，相对低氧可能与体育锻炼和内源性代谢的改变有关。医学界似乎没有能力解决所涉及的主要问题。我们有常压“缺氧室”的经验，现在将测试（体育锻炼）训练计划，使用德国其他地方没有的最先进的评估。我们将比较低氧室，环境训练，以测试的概念，即特定的运动条件可以调节特定的分子途径参与代谢综合征的发病机制。事实上，在降低心血管危险因素或改善健康方面，低氧室训练可能优于传统训练上级。我们将使用代谢室测试总体代谢相关影响。我们将在日常运动中用微透析测试局部代谢，我们将进行脂肪和肌肉活检以研究组织相关的影响。我们包括来自广泛领域的经验。我们的研究结果可能会提高对体育锻炼和内源性代谢机制的理解。此外，它们可能影响有关非药物干预的决策。