Analysis on the origin, function and regulation of B-chromosome located gene fragments
Analysis on the origin, function and regulation of B-chromosome located gene fragments
批准号:
221477818
负责人:
Privatdozent Dr. Andreas Houben
金额:
$0.0万
依托单位国家:
德国
项目类别:
Research Grants
财政年份:
2012
资助国家:
德国
项目状态:
已结题
起止时间:
2011-12-31 至 2014-12-31
中文摘要
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英文摘要
Bislang wurden B-Chromosomen (Bs) als „nicht-funktional“ und ohne kodierende Funktion beschrieben. Die Identifizierung von B-lokalisierten Gensequenzen mit Ähnlichkeit zu Kopien auf den Standard-Chromosomen (As) des Roggens war daher unerwartet. Ziel ist es, den Ursprung, Funktion and Regulation von B-lokalisierten Gen(fragment)en zu erkunden. Dazu soll die Sequenzabdeckung des B Chromosoms erhöht werden, um Aussagen zur Intaktheit und dem Ursprung von B-lokalisierten Genen treffen zu können. Der Transkriptionszustand, die Regulierung und das Zusammenspiel von A- und B-lokaliserten Genen soll mit Hilfe von „RNAseq“, RT-PCR und Methylierungsanalyse geprüft werden. Es werden Neuerkenntnisse zur Ausprägung von Phänotypen, die von Genkopiezahlen-abhängig sind, analog zu Aneuploidie, erwartet.
期刊论文(3)
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科研奖励(0)
会议论文
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