MRI: Acquisition of a 500 MHz NMR spectrometer with a cryoprobe for expanding interdisciplinary research and education at the Fresno State

MRI：购买一台带有冷冻探头的 500 MHz NMR 波谱仪，用于扩大弗雷斯诺州立大学的跨学科研究和教育

• 批准号: 1919908
• 负责人: Viswanathan Krishnan
• 金额: $ 107.1万
• 依托单位: California State University-Fresno Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-10-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1919908&HistoricalAwards=false
• 关键词: MRI; Acquisition; 500; MHz; NMR

An award is made to California State University, Fresno (Fresno State) to acquire a 500 MHz nuclear magnetic resonance (NMR) spectrometer with a cryoprobe. The instrument will be the centerpiece of the Fresno State NMR facility, which supports research, teaching, and student training across multiple disciplines including biology, biochemistry, biotechnology, chemistry, and physics. Fresno State serves a population with a high proportion of students that are traditionally under-represented in these disciplines including minority, first-generation, and socio-economically disadvantaged students. The spectrometer will be used to train over 50 undergraduate and graduate research students from diverse backgrounds each semester. The instrument will be used to modernize undergraduate and graduate laboratory classes and to incorporate 2D-NMR methods and multi-nuclear experiments. The NMR spectrometer will also be utilized in Course-Based Undergraduate Research Experiences (CUREs), which are being broadly implemented at Fresno State across the curriculum to improve access to research opportunities. Projects will strengthen ties and collaborations with the regional agricultural biotechnology industry, government research laboratories, and local community colleges.The project will support and enhance research across a broad spectrum of research areas. These include studies of the structure and dynamics of intrinsically disordered proteins, development of methods for real-time kinetics measurements, natural product/medicinal chemistry characterization, and several metabolomics studies. The project will also enable new projects to be initiated including characterization of nanomaterials, nanobody-antigen binding studies, and development of methods to investigate organic radical kinetics and mechanisms. Evaluations of CUREs will provide insights on embedding NMR-dependent research into the curriculum at a diverse, comprehensive institution.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

加州州立大学弗雷斯诺分校(弗雷斯诺州立大学)获得一台带有冷冻探头的500兆赫核磁共振(核磁共振)光谱仪。该仪器将是弗雷斯诺州立大学核磁共振设施的核心，该设施支持包括生物、生物化学、生物技术、化学和物理在内的多个学科的研究、教学和学生培训。弗雷斯诺州立大学服务的人群中有很大比例的学生在这些学科中传统上代表不足，包括少数族裔、第一代和社会经济条件较差的学生。该光谱仪每学期将用于培训50多名来自不同背景的本科生和研究生。该仪器将用于使本科生和研究生实验室课程现代化，并纳入2D-核磁共振方法和多核实验。核磁共振光谱仪还将用于以课程为基础的本科生研究体验(CURE)，这将在弗雷斯诺州立大学的整个课程中广泛实施，以改善获得研究机会的机会。项目将加强与区域农业生物技术行业、政府研究实验室和当地社区大学的联系和合作。该项目将支持和加强广泛研究领域的研究。这些包括对内在无序蛋白质的结构和动力学的研究，实时动力学测量方法的开发，天然产物/药物化学表征，以及几项代谢组学研究。该项目还将启动新的项目，包括纳米材料的表征、纳米体与抗原结合的研究，以及研究有机自由基动力学和机理的方法的开发。对CURE的评估将为将依赖于核磁共振的研究嵌入到多元化、综合性学院的课程中提供见解。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Targeted 19F-tags to detect amino acids in complex mixtures using NMR spectroscopy

• DOI: 10.1016/j.jfluchem.2022.110084
• 发表时间: 2023-01-05
• 期刊: JOURNAL OF FLUORINE CHEMISTRY
• 影响因子: 1.9
• 作者: Montgomery，Keeton;Elhabashy，Aya;Krishnan，V. V.
• 通讯作者: Krishnan，V. V.