MRI: Acquisition of a 500 MHz NMR spectrometer with a cryoprobe for expanding interdisciplinary research and education at the Fresno State

美国加州州立大学弗雷斯诺分校获得一台500兆赫核磁共振（NMR）光谱仪和一台冷冻探针。该仪器将成为弗雷斯诺州立核磁共振设施的核心，支持包括生物学、生物化学、生物技术、化学和物理学在内的多个学科的研究、教学和学生培训。弗雷斯诺州立大学的学生比例很高，这些学生传统上在这些学科中代表性不足，包括少数民族、第一代和社会经济上处于不利地位的学生。该光谱仪每学期将用于培养50多名来自不同背景的本科生和研究生。该仪器将用于现代化的本科和研究生实验室课程，并纳入二维核磁共振方法和多核实验。核磁共振谱仪也将用于基于课程的本科生研究经验（CUREs），这在弗雷斯诺州立大学的课程中广泛实施，以提高获得研究机会的机会。项目将加强与地区农业生物技术产业、政府研究实验室和当地社区大学的联系和合作。该项目将支持和加强广泛研究领域的研究。这些研究包括对内在无序蛋白质的结构和动力学的研究，实时动力学测量方法的开发，天然产物/药物化学表征，以及一些代谢组学研究。该项目还将启动新的项目，包括纳米材料的表征，纳米体抗原结合研究，以及研究有机自由基动力学和机制的方法的发展。对CUREs的评估将为将核磁共振相关研究纳入多元化综合性机构的课程提供见解。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

An award is made to California State University, Fresno (Fresno State) to acquire a 500 MHz nuclear magnetic resonance (NMR) spectrometer with a cryoprobe. The instrument will be the centerpiece of the Fresno State NMR facility, which supports research, teaching, and student training across multiple disciplines including biology, biochemistry, biotechnology, chemistry, and physics. Fresno State serves a population with a high proportion of students that are traditionally under-represented in these disciplines including minority, first-generation, and socio-economically disadvantaged students. The spectrometer will be used to train over 50 undergraduate and graduate research students from diverse backgrounds each semester. The instrument will be used to modernize undergraduate and graduate laboratory classes and to incorporate 2D-NMR methods and multi-nuclear experiments. The NMR spectrometer will also be utilized in Course-Based Undergraduate Research Experiences (CUREs), which are being broadly implemented at Fresno State across the curriculum to improve access to research opportunities. Projects will strengthen ties and collaborations with the regional agricultural biotechnology industry, government research laboratories, and local community colleges.The project will support and enhance research across a broad spectrum of research areas. These include studies of the structure and dynamics of intrinsically disordered proteins, development of methods for real-time kinetics measurements, natural product/medicinal chemistry characterization, and several metabolomics studies. The project will also enable new projects to be initiated including characterization of nanomaterials, nanobody-antigen binding studies, and development of methods to investigate organic radical kinetics and mechanisms. Evaluations of CUREs will provide insights on embedding NMR-dependent research into the curriculum at a diverse, comprehensive institution.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.