Membrane Attack Complex / Perforin like proteins in Defence, Attack and Developmental Biology
Membrane Attack Complex / Perforin like proteins in Defence, Attack and Developmental Biology
批准号:
FF0883418
负责人:
Prof James Whisstock
金额:
$117.9万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Federation Fellowships
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-12-31 至 2013-12-31
中文摘要
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英文摘要
This proposal will result in a major advancement of knowledge, for example, in our understanding of the emerging links between immunity and development as well as the role and mechanism of function of the pore forming family of MACPF proteins in host defence, attack, embryo development and diseases such as cancer. These data will be crucial for developing approaches to control unwanted MACPF function, for example in disease such as diabetes or transplant rejection. Furthermore, a detailed understanding of how MACPF proteins assemble into rings and punch holes in membranes will facilitate the development of these proteins as technological tools.
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会议论文
The structural basis for MPEG1 mediated assembly of immune complexes
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批准号:DP220103197
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项目类别:Discovery Projects
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负责人:Prof James Whisstock
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An in situ structural study of Drosophila embryonic patterning
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批准号:FL180100019
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项目类别:Australian Laureate Fellowships
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资助金额:$200.23万
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财政年份:2019
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负责人:Prof James Whisstock
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依托单位:
Controlling the function of pore forming perforin-like proteins in immune mediated disease
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批准号:nhmrc : GNT1154184
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项目类别:Research Fellowships
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资助金额:$88.83万
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财政年份:2019
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负责人:Prof James Whisstock
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依托单位:
Molecular basis for conjugative transfer of antibiotic resistance genes in Gram positive pathogens
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批准号:nhmrc : 1104502
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项目类别:Project Grants
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资助金额:$60.03万
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财政年份:2016
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负责人:Prof James Whisstock
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依托单位:
ARC Centre of Excellence in Advanced Molecular Imaging
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批准号:CE140100011
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项目类别:ARC Centres of Excellence
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资助金额:$2023.34万
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财政年份:2014
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负责人:Prof James Whisstock
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依托单位:
Proteolytic systems in Health and Disease
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批准号:nhmrc : GNT1059411
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项目类别:Research Fellowships
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资助金额:$82.29万
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财政年份:2014
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负责人:Prof James Whisstock
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依托单位:
Proteolytic systems in Health and Disease
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批准号:nhmrc : 1059411
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项目类别:Research Fellowships
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资助金额:$57.57万
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财政年份:2014
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负责人:Prof James Whisstock
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依托单位:
The evolution of Membrane Attack Complex / Perforin-like proteins in development and immunity
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批准号:DP140102771
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项目类别:Discovery Projects
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资助金额:$37.74万
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财政年份:2014
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负责人:Prof James Whisstock
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依托单位:
The mechanism of conjugative transfer of antibiotic resistance genes in Gram positive pathogens
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批准号:nhmrc : 1048676
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项目类别:Project Grants
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资助金额:$41.91万
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财政年份:2013
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负责人:Prof James Whisstock
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依托单位:
Understanding how perforin forms pores: the role of calcium and lipids.
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批准号:nhmrc : 1042858
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项目类别:Project Grants
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资助金额:$53.2万
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财政年份:2013
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负责人:Prof James Whisstock
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依托单位:
The structural basis for plasminogen activation
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批准号:nhmrc : 1042859
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项目类别:Project Grants
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资助金额:$37.06万
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财政年份:2013
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负责人:Prof James Whisstock
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依托单位:
A centre for structural cryo-electron microscopy
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批准号:LE120100090
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$42.68万
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财政年份:2012
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负责人:Prof James Whisstock
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依托单位:
Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells
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批准号:FS100100073
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项目类别:Super Science Fellowships
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资助金额:$59.65万
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财政年份:2011
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负责人:Prof James Whisstock
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依托单位:
Membrane attack complex/perforin-like proteins in developmental and neurobiology
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批准号:DP110100622
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项目类别:Discovery Projects
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资助金额:$27.42万
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财政年份:2011
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负责人:Prof James Whisstock
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依托单位:
Structural and Functional studies on Membrane Attack Complex / Perforin-like proteins
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批准号:DP0986811
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项目类别:Discovery Projects
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资助金额:$61.21万
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财政年份:2009
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负责人:Prof James Whisstock
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 436623
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项目类别:Research Fellowships
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资助金额:$28.89万
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财政年份:2007
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负责人:Prof James Whisstock
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依托单位:
Structural and functional studies on prokaryote serpins
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批准号:DP0663860
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项目类别:Discovery Projects
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资助金额:$20.34万
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财政年份:2006
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负责人:Prof James Whisstock
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依托单位:
Establishing a high-throughput Protein Production Unit
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批准号:LE0561042
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$56.86万
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财政年份:2005
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负责人:Prof James Whisstock
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依托单位:
Development of a collaborative environment for high throughput biology discovery pipelines.
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批准号:SR0567460
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项目类别:Special Research Initiatives
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资助金额:$5.84万
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财政年份:2005
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负责人:Prof James Whisstock
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依托单位:
Searching for novel protein domains: A bioinformatic analysis of whole proteomes
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批准号:DP0208103
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项目类别:Discovery Projects
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资助金额:$6.35万
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财政年份:2002
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负责人:Prof James Whisstock
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依托单位:
国内基金
海外基金
适应多类型Insider Attack的入侵检测与精确定位方法的研究
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批准号:60803161
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项目类别:青年科学基金项目
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资助金额:20.0万元
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批准年份:2008
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负责人:魏贵义
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依托单位: