The mechanism of conjugative transfer of antibiotic resistance genes in Gram positive pathogens

革兰氏阳性病原体中抗生素抗性基因的接合转移机制

• 批准号: nhmrc : 1048676
• 负责人: Prof James Whisstock
• 金额: $ 41.91万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanism-conjugative-transfer-positive-pathogens/112030
• 关键词: mechanism; conjugative; transfer; antibiotic; resistance

Antibiotic resistant bacteria pose a serious threat to the health of Australians. We will determine how antibiotic resistance genes spread from one bacterium to another. Using a disease-causing bacterium as model we will determine the mechanism by which this gene transfer process occurs and the structure and function of the key components. The result will be major advances in our understanding of the evolution of the antibiotic resistant bacteria that are major causes of human disease.

抗药性细菌对澳大利亚人的健康构成严重威胁。我们将确定抗生素耐药性基因如何从一种细菌传播到另一种细菌。以致病细菌为模型，我们将确定这一基因转移过程发生的机制以及关键成分的结构和功能。其结果将是我们在理解抗生素耐药细菌进化方面的重大进展，这些细菌是人类疾病的主要原因。