An in situ structural study of Drosophila embryonic patterning

果蝇胚胎模式的原位结构研究

• 批准号: FL180100019
• 负责人: Prof James Whisstock
• 金额: $ 200.23万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Australian Laureate Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FL180100019
• 关键词: situ; structural; study; Drosophila; embryonic

This project aims to develop and deploy an in situ structural biology approach, which enables direct visualisation of large macromolecular structures in cells, to be used in combination with molecular genetics, proteomics and computational biology. In situ structural biology has the potential to revolutionise discovery across life science, providing direct insight into macromolecular structure and function. This project will establish the field of in situ structural biology in Australia by studying how a model organism, the fruit fly Drosophila melanogaster controls the development of how the head and tail of the embryo are specified. The project will further develop new instrumentation and approaches that will bring in situ biology to the wider scientific community.

该项目旨在开发和部署一种原位结构生物学方法，该方法能够直接可视化细胞中的大分子结构，并与分子遗传学，蛋白质组学和计算生物学结合使用。原位结构生物学有可能彻底改变整个生命科学的发现，提供对大分子结构和功能的直接洞察。该项目将通过研究模式生物果蝇（Drosophila melanogaster）如何控制胚胎头部和尾部的发育，在澳大利亚建立原位结构生物学领域。该项目将进一步开发新的仪器和方法，将现场生物学带到更广泛的科学界。