课题基金 / 基金详情

The evolution of Membrane Attack Complex / Perforin-like proteins in development and immunity

The evolution of Membrane Attack Complex / Perforin-like proteins in development and immunity
膜攻击复合物/穿孔素样蛋白在发育和免疫中的进化
批准号：
DP140102771
负责人：
Prof James Whisstock
金额：
$37.74万
依托单位：
Monash University
依托单位国家：
澳大利亚
项目类别：
Discovery Projects
财政年份：
2014
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2014-01-01 至 2016-12-31
来源：
https://dataportal.arc.gov.au/RGS/Web/Grants/DP140102771
关键词：
evolutionMembraneAttackComplexPerforin

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中文摘要
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英文摘要
Membrane Attack Complex/Perforin-like (MACPF) proteins commonly play key roles in vertebrate immunity, however some family members play critical but poorly understood developmental roles. It has been shown that the sole Drosophila MACPF protein, Torsolike, plays both developmental and immune roles. Here the aim to unravel how Torsolike functions in these dual roles by using a novel genetic screening approach to identify genes needed for its function. The project also uses comparative studies to probe alternative functions of Torsolike in a second insect, the honeybee. This data will be pivotal for understanding how members of this family have evolved into proteins that are separately involved in immune defense and in development in higher vertebrates.
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