Molecular basis for conjugative transfer of antibiotic resistance genes in Gram positive pathogens

革兰氏阳性病原体中抗生素抗性基因接合转移的分子基础

• 批准号: nhmrc : 1104502
• 负责人: Prof James Whisstock
• 金额: $ 60.03万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-basis-conjugative-positive-pathogens/662755
• 关键词: Molecular; basis; conjugative; transfer; antibiotic

There has been growing concern about the increasing level of antibiotic resistance in bacterial pathogens. We will use a model genetic element to determine the mechanism by which an important class of pathogenic bacteria can acquire new resistance genes by a process known as horizontal gene transfer. The project will significantly enhance our understanding of how major hospital and community acquired pathogenic bacteria can rapidly evolve to become resistant to different antimicrobial agents.

人们越来越关注细菌病原体中抗生素耐药性水平的增加。我们将使用一个模型遗传元件来确定一类重要的病原菌通过一个称为水平基因转移的过程获得新的抗性基因的机制。该项目将大大提高我们对主要医院和社区获得性致病菌如何迅速进化成对不同抗菌药物具有耐药性的理解。