CAREER: Compact digital biosensing system enabled by localized acoustic streaming
职业:由局部声流驱动的紧凑型数字生物传感系统
基本信息
- 批准号:2144216
- 负责人:
- 金额:$ 50万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-06-01 至 2027-05-31
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Rapid, portable, and accurate diagnostic testing is of great importance to improve the quality and accessibility of healthcare. However, the performance of existing rapid and portable testing methods is often not sufficient for complex diseases such as infectious diseases, cancer, and cardiovascular diseases. The major goal of this CAREER project is to develop a new digital testing platform that offers high detection sensitivity and quantification accuracy without sacrificing the simplicity and the portability. The new testing platform is enabled by the unique fluid phenomenon induced by a vibrating capillary and 3D printed microdevices. Upon the successful completion of this project, integrated devices that can detect low abundance nucleic acid and protein biomarkers without the need of dedicated instrument and laboratory space will be developed. Such devices will have great potential to deliver high quality medical testing to a broad population including underserved communities and resource limited regions. This project is highly multidisciplinary and will produce low cost, and compact instrumentation. It therefore creates unique educational opportunities for students with diverse backgrounds. The proposal will enable 1) improved learning outcomes for students in quantitative chemical analysis lab through implementing project- and problem-based learning concepts to the curriculum; 2) novel microscale analytical chemistry experiments for undergraduate students, e.g., vibrating sharp-tip powered microfluidic enzymatic assay; 3) a research program that trains students to solve research problems using multidisciplinary approaches.This project is to develop an integrated solution to perform complete digital bioassays under a point-of-care (POC) setting thereby addressing the unmet need of developing high performance POC tests. The proposed method is enabled by controlling the vibration of sharp tips, which can generate localized and individually addressable acoustic streaming in microchannels for fluid control and droplet generation. To achieve the proposed impact, three aims will be pursued: 1) Elucidate the sharp-tip droplet generation process through numerical modeling and streaming analysis and demonstrate a POC nucleic acids detection system; 2) Develop a simple dual flow droplet generation system for performing digital ELISA; 3) Demonstrate an integrated the sample processing system enabled by vibrating sharp-tip and composable microfluidic plates. This project will lead to a flexible biosensing platform that can be easily adapted to measure either low abundance nucleic acids or protein biomarkers. It will also advance the fundamental understanding of the acoustic streaming in immiscible fluids and expand the utility of acoustic streaming for complex fluid, droplet, and particle manipulations.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
快速、便携和准确的诊断测试对于提高医疗质量和可及性至关重要。然而,现有的快速和便携式检测方法的性能往往不足以用于复杂的疾病,如传染病,癌症和心血管疾病。这个CAREER项目的主要目标是开发一个新的数字测试平台,提供高检测灵敏度和定量准确性,而不牺牲简单性和便携性。新的测试平台由振动毛细管和3D打印微器件引起的独特流体现象实现。该项目成功完成后,将开发出无需专用仪器和实验室空间即可检测低丰度核酸和蛋白质生物标志物的集成设备。这些设备将有很大的潜力为广大人群提供高质量的医学检测,包括服务不足的社区和资源有限的地区。该项目是高度多学科的,将产生低成本,紧凑的仪器。因此,它为不同背景的学生创造了独特的教育机会。该提案将使1)通过实施项目和问题为基础的学习理念,提高学生在定量化学分析实验室的学习成果; 2)为本科生提供新颖的微型分析化学实验,例如,振动尖端动力微流控酶测定; 3)一个研究项目,训练学生使用多学科方法解决研究问题。该项目旨在开发一种集成解决方案,在即时护理(POC)环境下进行完整的数字生物测定,从而解决未满足的需求开发高性能POC测试。所提出的方法通过控制尖锐尖端的振动来实现,这可以在微通道中产生局部的和可单独寻址的声流,用于流体控制和液滴生成。为了实现所提出的影响,将追求三个目标:1)通过数值建模和流分析阐明尖端液滴生成过程,并展示POC核酸检测系统; 2)开发用于执行数字ELISA的简单双流液滴生成系统; 3)展示通过振动尖端和可组合微流体板实现的集成样品处理系统。该项目将导致一个灵活的生物传感平台,可以很容易地适应于测量低丰度核酸或蛋白质生物标志物。它也将推进对不混溶流体中声流的基本理解,并扩大声流在复杂流体、液滴和颗粒操纵中的实用性。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Peng Li其他文献
Aspirin inhibits the proliferation of tobacco-related esophageal squamous carcinomas cell lines through cyclooxygenase 2 pathway.
阿司匹林通过环氧合酶2途径抑制烟草相关食管鳞状细胞系的增殖。
- DOI:
- 发表时间:
2007 - 期刊:
- 影响因子:6.1
- 作者:
Qiaozhi Zhou;Haibo Liu;Xinxin Ding;Peng Li;Shutian Zhang;Zhong - 通讯作者:
Zhong
Study of the Sheyuegou Dam breach – Experience with the post-failure investigation and back analysis
蛇月沟溃坝研究——溃后调查与反分析经验
- DOI:
10.1016/j.engfailanal.2021.105441 - 发表时间:
2021 - 期刊:
- 影响因子:4
- 作者:
Shu Yu;Qiang Zhang;Zuyu Chen;Jianwei Hao;Lin Wang;Peng Li;Qiming Zhong - 通讯作者:
Qiming Zhong
Formation mechanism of ZnO in dissimilar welding of aluminum alloy to steel
铝合金与钢异种材料焊接中ZnO的形成机理
- DOI:
10.1016/j.matlet.2018.06.070 - 发表时间:
2018-10 - 期刊:
- 影响因子:3
- 作者:
Honggang Dong;Pengxiao Wang;Xiaohu Hao;Shuai Li;Peng Li;Yulai Gao;Bingge Zhao;Dejun Yan - 通讯作者:
Dejun Yan
Asynchronous H∞ control of constrained Markovian jump linear systems with average dwell time
具有平均驻留时间的约束马尔可夫跳跃线性系统的异步 H 控制
- DOI:
- 发表时间:
2013 - 期刊:
- 影响因子:0
- 作者:
Wen Jiwei;Peng Li;Nguang Sing Kiong - 通讯作者:
Nguang Sing Kiong
The effect and mechanism of excessive iodine on the endothelial function of human umbilical vein endothelial cells
过量碘对人脐静脉内皮细胞内皮功能的影响及机制
- DOI:
10.1002/tox.23671 - 发表时间:
2022-09 - 期刊:
- 影响因子:0
- 作者:
D;an Wang;Peng Li;Lixiang Liu;Peng Liu;Zheng Zhou;Meihui Jin;Baoxiang Li;Fan Li;Yao Chen;Hongmei Shen - 通讯作者:
Hongmei Shen
Peng Li的其他文献
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{{ truncateString('Peng Li', 18)}}的其他基金
SHF: Small: Semi-supervised Learning for Design and Quality Assurance of Integrated Circuits
SHF:小型:集成电路设计和质量保证的半监督学习
- 批准号:
2334380 - 财政年份:2024
- 资助金额:
$ 50万 - 项目类别:
Standard Grant
SHF: Small: Methods and Architectures for Optimization and Hardware Acceleration of Spiking Neural Networks
SHF:小型:尖峰神经网络优化和硬件加速的方法和架构
- 批准号:
2310170 - 财政年份:2023
- 资助金额:
$ 50万 - 项目类别:
Standard Grant
Towards fault-tolerant, reliable, efficient, and economical DC-DC conversion for DC grid (FREE-DC)
面向直流电网实现容错、可靠、高效且经济的 DC-DC 转换 (FREE-DC)
- 批准号:
EP/X031608/1 - 财政年份:2023
- 资助金额:
$ 50万 - 项目类别:
Research Grant
Collaborative Research: SHF: Medium: Data-Efficient Uncovering of Rare Design Failures for Reliability-Critical Circuits
合作研究:SHF:中:以数据效率揭示可靠性关键电路的罕见设计故障
- 批准号:
1956313 - 财政年份:2020
- 资助金额:
$ 50万 - 项目类别:
Continuing Grant
Enabling Adaptive Voltage Regulation: Control, Machine Learning, and Circuit Design
实现自适应电压调节:控制、机器学习和电路设计
- 批准号:
2000851 - 财政年份:2019
- 资助金额:
$ 50万 - 项目类别:
Standard Grant
FET: Small: Heterogeneous Learning Architectures and Training Algorithms for Hardware Accelerated Deep Spiking Neural Computation
FET:小型:硬件加速深度尖峰神经计算的异构学习架构和训练算法
- 批准号:
1911067 - 财政年份:2019
- 资助金额:
$ 50万 - 项目类别:
Standard Grant
FET: Small: Heterogeneous Learning Architectures and Training Algorithms for Hardware Accelerated Deep Spiking Neural Computation
FET:小型:硬件加速深度尖峰神经计算的异构学习架构和训练算法
- 批准号:
1948201 - 财政年份:2019
- 资助金额:
$ 50万 - 项目类别:
Standard Grant
E2CDA: Type II: Self-Adaptive Reservoir Computing with Spiking Neurons: Learning Algorithms and Processor Architectures
E2CDA:类型 II:带尖峰神经元的自适应储层计算:学习算法和处理器架构
- 批准号:
1940761 - 财政年份:2019
- 资助金额:
$ 50万 - 项目类别:
Continuing Grant
Enabling Adaptive Voltage Regulation: Control, Machine Learning, and Circuit Design
实现自适应电压调节:控制、机器学习和电路设计
- 批准号:
1810125 - 财政年份:2018
- 资助金额:
$ 50万 - 项目类别:
Standard Grant
I-Corps: Enabling Electronic Design using Data Intelligence
I-Corps:使用数据智能实现电子设计
- 批准号:
1740531 - 财政年份:2017
- 资助金额:
$ 50万 - 项目类别:
Standard Grant
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