Ribosomal peptide secondary metabolites from fungi

真菌核糖体肽次级代谢产物

• 批准号: 317347381
• 负责人: Professor Dr. Roderich D. Süßmuth
• 金额: --
• 依托单位: Leiden Institute of Chemistry
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/317347381?language=en
• 关键词: Ribosomal; peptide; secondary; metabolites; fungi

Ribosomally synthesised and posttranslationally modified peptides display various interesting bioactivities. Therefore the investigation and the understanding of their biosynthesis is of particular importance, lastly also for the modification of structures aiming at an engineering of bioactivities and physiological functions. The goal of this project is the characterization of the biosynthesis of fungal secondary metabolites by enzymatic reactions (in vitro) and by heterologous expression in a host organism (in vivo). Currently there are only two representatives of fungal ribosomally synthesized peptides known: Ustiloxin and the amanitins/phalloidins. Remarkably, the enzymatics is not satisfyingly understood and required intensive research efforts.

核糖体合成和后修饰的肽显示出各种有趣的生物活性。因此，研究和了解它们的生物合成是特别重要的，最后也为结构的修改，旨在工程的生物活性和生理功能。该项目的目标是通过酶促反应（体外）和宿主生物体中的异源表达（体内）来表征真菌次级代谢产物的生物合成。目前已知的真菌核糖体合成肽只有两种代表：Ustiloxin和鹅膏蕈菌素/鬼笔环肽。值得注意的是，酶的理解并不令人满意，需要深入的研究工作。