Ribosomal peptide secondary metabolites from fungi

真菌核糖体肽次级代谢产物

• 批准号: 317347381
• 负责人: Professor Dr. Roderich D. Süßmuth
• 金额: --
• 依托单位: Leiden Institute of Chemistry
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/317347381?language=en
• 关键词: Ribosomal; peptide; secondary; metabolites; fungi

Ribosomally synthesised and posttranslationally modified peptides display various interesting bioactivities. Therefore the investigation and the understanding of their biosynthesis is of particular importance, lastly also for the modification of structures aiming at an engineering of bioactivities and physiological functions. The goal of this project is the characterization of the biosynthesis of fungal secondary metabolites by enzymatic reactions (in vitro) and by heterologous expression in a host organism (in vivo). Currently there are only two representatives of fungal ribosomally synthesized peptides known: Ustiloxin and the amanitins/phalloidins. Remarkably, the enzymatics is not satisfyingly understood and required intensive research efforts.

核糖体合成和翻译后修饰的肽表现出各种有趣的生物活性。因此，研究及其对生物合成的理解尤其重要，最后也用于修改针对生物活性和生理功能工程的结构。该项目的目的是通过酶促反应（体外）和宿主有机体（体内）中异源表达来表征真菌次生代谢产物的生物合成。目前，只有两名已知的真菌核糖体合成肽的代表：乌斯利毒素和氨基氨酸蛋白/腓骨蛋白。值得注意的是，酶促学并不令人满意地理解，需要进行深入的研究工作。