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Tailor-maid cancer prevention towards the era of preemptive medicine.

迈向抢先医学时代的量身定制癌症预防。

基本信息

批准号：
19H01079
负责人：
酒井敏行
金额：
$ 28.62万
依托单位：
Kyoto Prefectural University of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2019
资助国家：
日本
起止时间：
2019-04-01 至 2024-03-31
项目状态：
已结题

项目摘要

近年、個別に疾患のリスクを遺伝子診断し、個々が発症する前に予防介入を行う「先制医療」が、国策としても極めて重要であることが叫ばれ始めた。研究代表者らは、約25年も前から、がんのハイリスク集団に対するテーラーメイド予防研究を行ってきた。本研究課題では、「家族性大腸腺腫症」と「リ・フラウメニ症候群」の未発症変異保有者の発がんリスクの軽減を目標に、今までの実績を基に、その集大成として、実際にがんの先制医療を可能とする基礎的研究を完成させたい。まず、発がん抑制に重要ながん抑制遺伝子であるRBに着目し、RB活性化作用、抗炎症作用を有する食品成分の文献調査を行った。遺伝的にがん抑制遺伝子APCが失活している「家族性大腸腺腫症」の未発症変異保有者に対する先制医療研究として、文献調査で選定してきた食品成分、すなわち「がん予防カクテル候補成分」を、APC遺伝子に変異を有するヒト大腸がん細胞株SW480に投与し、細胞の増殖抑制効果を測定し、その情報を収集してきた。新たな「がん予防カクテル候補成分」の細胞増殖抑制効果を継続して検証しつつ、MEK阻害剤トラメチニブと、これら候補成分の併用効果の検証試験を行った。トラメチニブは、がん細胞の異常増殖に寄与するMEKの機能を阻害することで、がん細胞内の増殖シグナルを強力に抑制することができる画期的分子標的薬であり、本研究課題の研究代表者が製薬企業との共同研究により見出し、上市に至った薬剤である。トラメチニブ単剤投与に対し、上記「がん予防カクテル候補成分」とトラメチニブとの組み合わせによる相乗効果について検証を行った。その結果、トラメチニブの併用時に細胞周期停止増強効果、アポトーシス誘導増強効果を有する複数の化合物を見出した。これらの化合物とトラメチニブとの併用効果において重要な働きを有する分子の探索を行い、複数の候補分子を見出している。

In recent years, patients with various diseases and diseases have been prevented from interventional therapy in the past few years, and the national policy has been very active in calling important health care providers. The representative of the research, about 25 years ago, participated in the study of preventive research. In this study, we have completed the study of "familial adenosis", "familial The effects of RB targeting, activating RB, and anti-inflammation include food ingredients, literatures, and so on. In the literature, we selected the ingredients of the food, the ingredients of the food, the ingredients of the APC, the ingredients of the cells, the cells of the plant, the cells of the plant, the cell line of the cell line, and the cell line. I love you so much that I love you. The new drug is used to prevent the occurrence of phenotypic ingredients. The colonization of the host cells inhibits the growth of the fruit, the MEK blocks the phenotype, and the candidate ingredient is used to prevent the infection. In this study, the representative of the research project, the representative of the research project, has been involved in the joint study of the market, the market and the market. In this study, the representative of the research project, the representative of the research project, has the ability to block the growth of the molecule in the drawing period, and the representative of the research project, the representative of the research team, the research representative of this study, the representative of this study, the representative of the research project, the representative of this study, the representative of the research project, the representative of the research project, the representative of this study, the representative of this study, the representative of the research project, the representative of this study, the representative of the research project, the representative of this study, the representative of this study, the representative of the research project, the representative of this study, the representative of this study, You need to know that you are not in the market, and that you need to know that you are not in the market, and that you are in good health. The results showed that the cell cycle stopped and the complex compounds were detected. The chemical compound is used to determine whether it is important to have a molecular exploration line, and a complex number of candidate molecules to get out of it.