Molecular structure and function of the glycine receptor
Molecular structure and function of the glycine receptor
批准号:
DP0773954
负责人:
Prof Joseph Lynch
金额:
$18.25万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2007
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2007-01-01 至 2009-12-31
中文摘要
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英文摘要
This proposal will employ a cutting edge approach to reveal fundamental new insights into the ways that ligand-gated ion channels, and proteins in general, work. The new knowledge and technology developed here will broaden and strengthen Australia's research expertise across a number of basic scientific disciplines. The results will also have relevance to human health. Glycine receptors have an essential role in brain function and are targets for anaesthetics and drugs of abuse. GlyRs are also important in modulating pain sensation by the brain. New insights into how natural agonists and drugs affect ion channel structure and function may lead to novel therapeutic opportunities and improved drug structure predictions.
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会议论文
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New tools to activate and silence neural circuits
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批准号:LP120100297
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Understanding the mechanisms of GABA type-A receptor activation and drug modulation
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Developing novel selective glycine receptor potentiators as a means to control pain.
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依托单位:
Activation mechanisms of Cys-loop ion channel receptors
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资助金额:$24.24万
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财政年份:2010
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负责人:Prof Joseph Lynch
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 569570
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项目类别:NHMRC Research Fellowships
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资助金额:$42.79万
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财政年份:2009
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负责人:Prof Joseph Lynch
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依托单位:
Identification of novel therapeutic binding sites on glycine receptors by high throughput screening
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批准号:nhmrc : 511169
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项目类别:NHMRC Project Grants
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资助金额:$36.14万
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财政年份:2008
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负责人:Prof Joseph Lynch
-
依托单位:
Therapeutic potential of glycine receptors in pain sensory pathways
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批准号:nhmrc : 455931
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项目类别:NHMRC Project Grants
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资助金额:$19.49万
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依托单位:
Subunit stoichiometry and arrangement in the glycine receptor
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资助金额:$16.71万
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财政年份:2004
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依托单位:
Tropisetron: molecular mechanisms of action at the 5-HT3 receptor and the glycine receptor
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批准号:nhmrc : 301053
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项目类别:NHMRC Project Grants
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资助金额:$24.79万
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财政年份:2004
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负责人:Prof Joseph Lynch
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 301023
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项目类别:NHMRC Research Fellowships
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资助金额:$38.92万
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财政年份:2004
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负责人:Prof Joseph Lynch
-
依托单位:
国内基金
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