Identification of novel therapeutic binding sites on glycine receptors by high throughput screening

通过高通量筛选鉴定甘氨酸受体上的新型治疗结合位点

• 批准号: nhmrc : 511169
• 负责人: Prof Joseph Lynch
• 金额: $ 36.14万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-novel-therapeutic-throughput-screening/100205
• 关键词: Identification; novel; therapeutic; binding; sites

Glycine receptors mediate inhibitory neurotransmission in the nervous system. They provide fresh therapeutic targets for chronic inflammatory pain and muscle spasticity. Here we identify 5 compounds that may be appropriate as leads for discovering novel therapies for these disorders. We will use automated high throughput screening methods to discover how these drugs interact with the receptor. This will narrow down the search for the next generation of analgesic and muscle relaxant drugs.

甘氨酸受体介导神经系统中的抑制性神经传递。它们为慢性炎性疼痛和肌肉痉挛提供了新的治疗靶点。在这里，我们确定了5种化合物，可能适合作为发现这些疾病的新疗法的线索。我们将使用自动化高通量筛选方法来发现这些药物如何与受体相互作用。这将缩小寻找下一代止痛药和肌肉松弛药的范围。