The role of zinc in synaptic transmission in the central nervous system

锌在中枢神经系统突触传递中的作用

• 批准号: DP150102428
• 负责人: Prof Joseph Lynch
• 金额: $ 25.52万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150102428
• 关键词: role; zinc; synaptic; transmission; central

By regulating the strength of synaptic transmission between neurons, zinc exerts dynamic control over many physiological processes including memory formation, fear conditioning and movement control. Zinc also controls neuronal cell death pathways. There is currently much controversy about the concentration that zinc reaches in the synaptic cleft and the length of time it remains elevated. By defining these parameters, this project aims to understand which proteins zinc acts upon and the molecular mechanisms by which it exerts its synapse-modulating effects. The outcomes of this project could lead to better understanding of zinc dynamics that could underpin future research into many physiological processes.

锌通过调节神经元间突触传递的强度，对记忆形成、恐惧调节和运动控制等许多生理过程施加动态控制。锌还控制神经元细胞的死亡途径。目前关于锌在突触间隙中的浓度及其持续升高的时间有很多争议。通过定义这些参数，本项目旨在了解锌作用于哪些蛋白质以及锌发挥其突触调节作用的分子机制。该项目的结果可能会导致更好地理解锌动力学，这可能会支持未来对许多生理过程的研究。