The role of zinc in synaptic transmission in the central nervous system
The role of zinc in synaptic transmission in the central nervous system
批准号:
DP150102428
负责人:
Prof Joseph Lynch
金额:
$25.52万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2018-06-30
中文摘要
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英文摘要
By regulating the strength of synaptic transmission between neurons, zinc exerts dynamic control over many physiological processes including memory formation, fear conditioning and movement control. Zinc also controls neuronal cell death pathways. There is currently much controversy about the concentration that zinc reaches in the synaptic cleft and the length of time it remains elevated. By defining these parameters, this project aims to understand which proteins zinc acts upon and the molecular mechanisms by which it exerts its synapse-modulating effects. The outcomes of this project could lead to better understanding of zinc dynamics that could underpin future research into many physiological processes.
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会议论文
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Developing novel selective glycine receptor potentiators as a means to control pain.
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Activation mechanisms of Cys-loop ion channel receptors
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Identification of novel therapeutic binding sites on glycine receptors by high throughput screening
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依托单位:
Therapeutic potential of glycine receptors in pain sensory pathways
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Molecular structure and function of the glycine receptor
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Tropisetron: molecular mechanisms of action at the 5-HT3 receptor and the glycine receptor
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资助金额:$38.92万
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依托单位:
国内基金
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