Activation mechanisms of Cys-loop ion channel receptors
Activation mechanisms of Cys-loop ion channel receptors
批准号:
DP1092582
负责人:
Prof Joseph Lynch
金额:
$24.24万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2012-12-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
This proposal will employ a cutting edge approach to reveal fundamental new insights into the ways that proteins work. The information and technology developed here will broaden and strengthen Australia's research expertise across a number of basic scientific disciplines. The results will also have relevance to human health. Cys-loop ligand-gated receptors have an essential role in brain function and are targets for many therapies and drugs of abuse. New insights into how biological ligands and drugs affect ion channel structure and function may lead to novel therapeutic opportunities and improved drug structure predictions.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
The Effects of Human Epilepsy Mutations on Synaptic GABA-A Receptors Studied by Localization-based Superresolution Microscopy
-
批准号:nhmrc : 1147600
-
项目类别:Project Grants
-
资助金额:$34.95万
-
财政年份:2018
-
负责人:Prof Joseph Lynch
-
依托单位:
The alpha5 GABA-A receptor: delineating an emerging therapeutic target
-
批准号:nhmrc : GNT1120947
-
项目类别:Project Grants
-
资助金额:$48.12万
-
财政年份:2017
-
负责人:Prof Joseph Lynch
-
依托单位:
The alpha5 GABA-A receptor: delineating an emerging therapeutic target
-
批准号:nhmrc : 1120947
-
项目类别:Project Grants
-
资助金额:$32.84万
-
财政年份:2017
-
负责人:Prof Joseph Lynch
-
依托单位:
The role of zinc in synaptic transmission in the central nervous system
-
批准号:DP150102428
-
项目类别:Discovery Projects
-
资助金额:$25.52万
-
财政年份:2015
-
负责人:Prof Joseph Lynch
-
依托单位:
A novel mechanism for therapeutically modulating neurotransmitter-activated ion channels
-
批准号:nhmrc : 1060707
-
项目类别:Project Grants
-
资助金额:$44.51万
-
财政年份:2014
-
负责人:Prof Joseph Lynch
-
依托单位:
Finding new ways to treat pain and anxiety disorders
-
批准号:nhmrc : GNT1058542
-
项目类别:Research Fellowships
-
资助金额:$72.76万
-
财政年份:2014
-
负责人:Prof Joseph Lynch
-
依托单位:
Inhibitory neurotransmitter receptors as therapeutic targets for chronic pain and anxiety disorders
-
批准号:nhmrc : 1058542
-
项目类别:Research Fellowships
-
资助金额:$50.9万
-
财政年份:2014
-
负责人:Prof Joseph Lynch
-
依托单位:
Inhibitory receptors in the amygdala
-
批准号:nhmrc : GNT1062183
-
项目类别:Project Grants
-
资助金额:$71.19万
-
财政年份:2014
-
负责人:Prof Joseph Lynch
-
依托单位:
Function and physiological role of inhibitory circuits in the amygdala
-
批准号:nhmrc : 1062183
-
项目类别:Project Grants
-
资助金额:$49.44万
-
财政年份:2014
-
负责人:Prof Joseph Lynch
-
依托单位:
The molecular basis of ionic selectivity in nicotinic-type ion channel receptors
-
批准号:DP130101702
-
项目类别:Discovery Projects
-
资助金额:$24.87万
-
财政年份:2013
-
负责人:Prof Joseph Lynch
-
依托单位:
New tools to activate and silence neural circuits
-
批准号:LP120100297
-
项目类别:Linkage Projects
-
资助金额:$32.92万
-
财政年份:2012
-
负责人:Prof Joseph Lynch
-
依托单位:
Understanding the mechanisms of GABA type-A receptor activation and drug modulation
-
批准号:DP120104373
-
项目类别:Discovery Projects
-
资助金额:$20.42万
-
财政年份:2012
-
负责人:Prof Joseph Lynch
-
依托单位:
Developing novel selective glycine receptor potentiators as a means to control pain.
-
批准号:nhmrc : 631448
-
项目类别:NHMRC Project Grants
-
资助金额:$36.85万
-
财政年份:2010
-
负责人:Prof Joseph Lynch
-
依托单位:
Uncoupled Research Fellowship
-
批准号:nhmrc : 569570
-
项目类别:NHMRC Research Fellowships
-
资助金额:$42.79万
-
财政年份:2009
-
负责人:Prof Joseph Lynch
-
依托单位:
Identification of novel therapeutic binding sites on glycine receptors by high throughput screening
-
批准号:nhmrc : 511169
-
项目类别:NHMRC Project Grants
-
资助金额:$36.14万
-
财政年份:2008
-
负责人:Prof Joseph Lynch
-
依托单位:
Therapeutic potential of glycine receptors in pain sensory pathways
-
批准号:nhmrc : 455931
-
项目类别:NHMRC Project Grants
-
资助金额:$19.49万
-
财政年份:2007
-
负责人:Prof Joseph Lynch
-
依托单位:
Molecular structure and function of the glycine receptor
-
批准号:DP0773954
-
项目类别:Discovery Projects
-
资助金额:$18.25万
-
财政年份:2007
-
负责人:Prof Joseph Lynch
-
依托单位:
Subunit stoichiometry and arrangement in the glycine receptor
-
批准号:DP0451836
-
项目类别:Discovery Projects
-
资助金额:$16.71万
-
财政年份:2004
-
负责人:Prof Joseph Lynch
-
依托单位:
Tropisetron: molecular mechanisms of action at the 5-HT3 receptor and the glycine receptor
-
批准号:nhmrc : 301053
-
项目类别:NHMRC Project Grants
-
资助金额:$24.79万
-
财政年份:2004
-
负责人:Prof Joseph Lynch
-
依托单位:
Uncoupled Research Fellowship
-
批准号:nhmrc : 301023
-
项目类别:NHMRC Research Fellowships
-
资助金额:$38.92万
-
财政年份:2004
-
负责人:Prof Joseph Lynch
-
依托单位:
国内基金
海外基金
登录
查看更多内容
Exploring the Intrinsic Mechanisms of CEO Turnover and Market
-
批准号:--
-
项目类别:外国学者研究基金
-
资助金额:--
-
批准年份:2024
-
负责人:HAOFEI Z
-
依托单位:
Exploring the Intrinsic Mechanisms of CEO Turnover and Market Reaction: An Explanation Based on Information Asymmetry
-
批准号:W2433169
-
项目类别:外国学者研究基金项目
-
资助金额:--
-
批准年份:2024
-
负责人:HAOFEI ZHANG
-
依托单位:
Erk1/2/CREB/BDNF通路在CSF1R相关性白质脑病致病机制中的作用研究
-
批准号:82371255
-
项目类别:面上项目
-
资助金额:49.00万元
-
批准年份:2023
-
负责人:曹立
-
依托单位:
Foxc2介导Syap1/Akt信号通路调控破骨/成骨细胞分化促进颞下颌关节骨关节炎的机制研究
-
批准号:82370979
-
项目类别:面上项目
-
资助金额:48.00万元
-
批准年份:2023
-
负责人:张善勇
-
依托单位:
MYRF/SLC7A11调控施万细胞铁死亡在三叉神经痛脱髓鞘病变中的作用和分子机制研究
-
批准号:82370981
-
项目类别:面上项目
-
资助金额:48.00万元
-
批准年份:2023
-
负责人:陈敏洁
-
依托单位:
Idh3a作为线粒体代谢—表观遗传检查点调控产热脂肪功能的机制研究
-
批准号:82370851
-
项目类别:面上项目
-
资助金额:48.00万元
-
批准年份:2023
-
负责人:包玉倩
-
依托单位:
小脑浦肯野细胞突触异常在特发性震颤中的作用机制及靶向干预研究
-
批准号:82371248
-
项目类别:面上项目
-
资助金额:47.00万元
-
批准年份:2023
-
负责人:吴逸雯
-
依托单位:
用于小尺寸管道高分辨成像荧光聚合物点的构建、成像机制及应用研究
-
批准号:82372015
-
项目类别:面上项目
-
资助金额:48.00万元
-
批准年份:2023
-
负责人:熊丽琴
-
依托单位:
声致离子电流促进小胶质细胞M2极化阻断再生神经瘢痕退变免疫机制
-
批准号:82371973
-
项目类别:面上项目
-
资助金额:48.00万元
-
批准年份:2023
-
负责人:孙迪
-
依托单位:
GREB1突变介导雌激素受体信号通路导致深部浸润型子宫内膜异位症的分子遗传机制研究
-
批准号:82371652
-
项目类别:面上项目
-
资助金额:45.00万元
-
批准年份:2023
-
负责人:刘开江
-
依托单位: