The Effects of Human Epilepsy Mutations on Synaptic GABA-A Receptors Studied by Localization-based Superresolution Microscopy

基于定位的超分辨率显微镜研究人类癫痫突变对突触 GABA-A 受体的影响

• 批准号: nhmrc : 1147600
• 负责人: Prof Joseph Lynch
• 金额: $ 34.95万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/effects-human-epilepsy-superresolution-microscopy/1320889
• 关键词: Effects; Human; Epilepsy; Mutations; Synaptic

The genetic epilepsies are debilitating neurological disorders that are frequently associated with mutations in genes encoding neurotransmitter-gated receptors in the brain. The goal of this project is to understand mechanisms that cause changes in neuronal communication and lead to epilepsy on a single receptor level. This will lead to an improved understanding of the mechanisms of epileptogenesis and new insights into ways of treating different epilepsies.

遗传性癫痫是一种使人衰弱的神经系统疾病，通常与大脑中编码神经递质门控受体的基因突变有关。该项目的目标是了解引起神经元通信变化并在单个受体水平上导致癫痫的机制。这将导致对癫痫发生机制的更好理解和对不同癫痫治疗方法的新见解。