The alpha5 GABA-A receptor: delineating an emerging therapeutic target
The alpha5 GABA-A receptor: delineating an emerging therapeutic target
批准号:
nhmrc : GNT1120947
负责人:
Prof Joseph Lynch
金额:
$48.12万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 --
中文摘要
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英文摘要
GABA-A receptors mediate inhibitory synaptic transmission in the brain. Receptors containing α5 subunits are therapeutic targets for many neurological disorders. We aim to characterise the functional properties of the main α5-containing isoforms using high-resolution imaging and whole-cell recording. Our goal is to understand which α5-containing isoform should be preferentially targeted (and how) when seeking to treat the various disorders in which these receptors have been implicated.
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The Effects of Human Epilepsy Mutations on Synaptic GABA-A Receptors Studied by Localization-based Superresolution Microscopy
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批准号:nhmrc : 1147600
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项目类别:Project Grants
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资助金额:$34.95万
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财政年份:2018
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负责人:Prof Joseph Lynch
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依托单位:
The alpha5 GABA-A receptor: delineating an emerging therapeutic target
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批准号:nhmrc : 1120947
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项目类别:Project Grants
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资助金额:$32.84万
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财政年份:2017
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负责人:Prof Joseph Lynch
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依托单位:
The role of zinc in synaptic transmission in the central nervous system
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批准号:DP150102428
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项目类别:Discovery Projects
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资助金额:$25.52万
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财政年份:2015
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负责人:Prof Joseph Lynch
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依托单位:
A novel mechanism for therapeutically modulating neurotransmitter-activated ion channels
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批准号:nhmrc : 1060707
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项目类别:Project Grants
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资助金额:$44.51万
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财政年份:2014
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负责人:Prof Joseph Lynch
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依托单位:
Finding new ways to treat pain and anxiety disorders
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批准号:nhmrc : GNT1058542
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项目类别:Research Fellowships
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资助金额:$72.76万
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财政年份:2014
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负责人:Prof Joseph Lynch
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依托单位:
Inhibitory neurotransmitter receptors as therapeutic targets for chronic pain and anxiety disorders
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批准号:nhmrc : 1058542
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项目类别:Research Fellowships
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资助金额:$50.9万
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财政年份:2014
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负责人:Prof Joseph Lynch
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依托单位:
Inhibitory receptors in the amygdala
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批准号:nhmrc : GNT1062183
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项目类别:Project Grants
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资助金额:$71.19万
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财政年份:2014
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负责人:Prof Joseph Lynch
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依托单位:
Function and physiological role of inhibitory circuits in the amygdala
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批准号:nhmrc : 1062183
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项目类别:Project Grants
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资助金额:$49.44万
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财政年份:2014
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负责人:Prof Joseph Lynch
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依托单位:
The molecular basis of ionic selectivity in nicotinic-type ion channel receptors
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批准号:DP130101702
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项目类别:Discovery Projects
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资助金额:$24.87万
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财政年份:2013
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负责人:Prof Joseph Lynch
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依托单位:
New tools to activate and silence neural circuits
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批准号:LP120100297
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项目类别:Linkage Projects
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资助金额:$32.92万
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财政年份:2012
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负责人:Prof Joseph Lynch
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依托单位:
Understanding the mechanisms of GABA type-A receptor activation and drug modulation
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批准号:DP120104373
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项目类别:Discovery Projects
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资助金额:$20.42万
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财政年份:2012
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负责人:Prof Joseph Lynch
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依托单位:
Developing novel selective glycine receptor potentiators as a means to control pain.
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批准号:nhmrc : 631448
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项目类别:NHMRC Project Grants
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资助金额:$36.85万
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财政年份:2010
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负责人:Prof Joseph Lynch
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依托单位:
Activation mechanisms of Cys-loop ion channel receptors
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批准号:DP1092582
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项目类别:Discovery Projects
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资助金额:$24.24万
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财政年份:2010
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负责人:Prof Joseph Lynch
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 569570
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项目类别:NHMRC Research Fellowships
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资助金额:$42.79万
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财政年份:2009
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负责人:Prof Joseph Lynch
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依托单位:
Identification of novel therapeutic binding sites on glycine receptors by high throughput screening
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批准号:nhmrc : 511169
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项目类别:NHMRC Project Grants
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资助金额:$36.14万
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财政年份:2008
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负责人:Prof Joseph Lynch
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依托单位:
Therapeutic potential of glycine receptors in pain sensory pathways
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批准号:nhmrc : 455931
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项目类别:NHMRC Project Grants
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资助金额:$19.49万
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财政年份:2007
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负责人:Prof Joseph Lynch
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依托单位:
Molecular structure and function of the glycine receptor
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批准号:DP0773954
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项目类别:Discovery Projects
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资助金额:$18.25万
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财政年份:2007
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负责人:Prof Joseph Lynch
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依托单位:
Subunit stoichiometry and arrangement in the glycine receptor
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批准号:DP0451836
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项目类别:Discovery Projects
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资助金额:$16.71万
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财政年份:2004
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负责人:Prof Joseph Lynch
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依托单位:
Tropisetron: molecular mechanisms of action at the 5-HT3 receptor and the glycine receptor
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批准号:nhmrc : 301053
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项目类别:NHMRC Project Grants
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资助金额:$24.79万
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财政年份:2004
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负责人:Prof Joseph Lynch
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 301023
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项目类别:NHMRC Research Fellowships
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资助金额:$38.92万
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财政年份:2004
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负责人:Prof Joseph Lynch
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依托单位:
国内基金
海外基金
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