The alpha5 GABA-A receptor: delineating an emerging therapeutic target

α5 GABA-A 受体：描绘一个新兴的治疗靶点

• 批准号: nhmrc : GNT1120947
• 负责人: Prof Joseph Lynch
• 金额: $ 48.12万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/alpha5-gaba-a-therapeutic-target/1347175
• 关键词: alpha5; GABA; receptor; delineating; emerging

GABA-A receptors mediate inhibitory synaptic transmission in the brain. Receptors containing α5 subunits are therapeutic targets for many neurological disorders. We aim to characterise the functional properties of the main α5-containing isoforms using high-resolution imaging and whole-cell recording. Our goal is to understand which α5-containing isoform should be preferentially targeted (and how) when seeking to treat the various disorders in which these receptors have been implicated.

GABA-A受体介导脑中的抑制性突触传递。含有α5亚基的受体是许多神经系统疾病的治疗靶点。我们的目标是使用高分辨率成像和全细胞记录来确定主要的含α5亚型的功能特性。我们的目标是了解在寻求治疗与这些受体有关的各种疾病时，应优先靶向（以及如何）哪种含α5的亚型。