The roles of the TAK1-Pim-2 pathway in drug resistance and bone destruction in multiple myeloma and development of novel agents to conquer them

TAK1-Pim-2 通路在多发性骨髓瘤耐药性和骨质破坏中的作用以及克服这些问题的新型药物的开发

• 批准号: 18K08329
• 负责人: ABE Masahiro
• 金额: $ 2.66万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2018
• 资助国家: 日本
• 起止时间: 2018-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18K08329/
• 关键词: 多発性骨髄腫; 骨髄微小環境; 薬剤耐性; 骨破壊; TAK1; PIM2; 阻害薬; 破骨細胞; 骨形成; 骨髄腫; TAK-1; 骨病変; TAK１; Pim-2; 骨髄間質細胞

项目成果

PD-L1 upregulation in myeloma cells by panobinostat in combination with interferon-γ

帕比司他联合干扰素-γ 上调骨髓瘤细胞中的 PD-L1

• 发表时间: 2019
• 期刊: Oncotarget
• 作者: Iwasa M;Harada T;Oda A;Bat-Erdene A;Teramachi J;TenshinT;Ashtar M;Oura M;Sogabe K;Udaka K;Fujii S;Nakamura S;Miki H;Kagawa K;Ozaki S and Abe M
• 通讯作者: Ozaki S and Abe M

Polyclonal Immunoglobulin Recovery after Autologous Stem Cell Transplantation Is an Independent Prognostic Factor for Survival Outcome in Patients with Multiple Myeloma

• DOI: 10.3390/cancers12010012
• 发表时间: 2020-01-01
• 期刊: CANCERS
• 影响因子: 5.2
• 作者: Ozaki, Shuji;Harada, Takeshi;Abe, Masahiro
• 通讯作者: Abe, Masahiro

Effect of serum concentration and concomitant drugs on vancomycin-induced acute kidney injury in haematologic patients: a single-centre retrospective study

血液病患者血清浓度及合并用药对万古霉素所致急性肾损伤的影响：单中心回顾性研究

• DOI: 10.1007/s00228-019-02756-4
• 发表时间: 2019
• 期刊: Eur J Clin Pharmacol
• 影响因子: 2.9
• 作者: Okada N;Chuma M;Azuma M;Nakamura S;Miki H;Hamano H;Goda M;Takechi K;Zamami Y;Abe M;Ishizawa K
• 通讯作者: Ishizawa K

Activation of unliganded FGF receptor by extracellular phosphate potentiates proteolytic protection of FGF23 by its O-glycosylation

• DOI: 10.1073/pnas.1815166116
• 发表时间: 2019-06-04
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Takashi, Yuichi;Kosako, Hidetaka;Fukumoto, Seiji
• 通讯作者: Fukumoto, Seiji

Management of patients with MGUS or multiple myeloma

MGUS 或多发性骨髓瘤患者的治疗

• 发表时间: 2018
• 作者: 内田奈生;菊池敦生;高橋俊成;松木琢磨;菅原典子;熊谷直憲;藤原幾磨;森貞直哉;野津寛大;飯島一誠;呉繁夫;Masahiro Abe
• 通讯作者: Masahiro Abe