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The research of mechanisms between shear stress and caveola in the liver regeneration and liver injury

The research of mechanisms between shear stress and caveola in the liver regeneration and liver injury
剪切应力和小凹在肝再生和肝损伤中的机制研究
批准号:
24659601
负责人:
SATO Yoshinobu
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31

项目摘要

项目成果

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中文摘要
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英文摘要
Last year, I changed my work location from Niigata Univ. to Showa Univ. Therefore, I could not perform the scheduled program. We intended to investigate comprehensively about a role of Caveolin-1 and PAI-1 in the liver. The clinicopathological analyses were made in the regenerative liver, steatotic liver, metastatic liver, and primary hepatocellular carcinoma and the mechanisms of regeneration, carcinogenesis, inflammation, and cancer metastasis were studied. Pilot study by immunological staining of the metastatic liver of colon cancer with caveolin-1, PAI-1, MT1-MMP, CD44 were performed. I could recognize the interesting findings that both the specimen of metastatic liver and primary colon cancer in Type 5 of colon cancer revealed the augmentation of PAI-1 staining.
期刊论文(9)
专著(0)
科研奖励(0)
会议论文
Catheter-directed continuous thrombolysis following aspiration thrombectomy via the ileocolic route for acute portal venous thrombosis: report of two cases.
经回结肠途径抽吸血栓切除术后导管引导持续溶栓治疗急性门静脉血栓:两例报告。
DOI: --
发表时间: 2013
期刊: Surgery Today
影响因子: 2.5
作者: [Miura K, Sato Y*, Nakatsuka H, Yamamoto S, Oya H, Hara Y, Kokai H, Hatakeyama K.]
通讯作者: Hatakeyama K.
Successful laparoscopic division of patent ductus venosus : Report of a Case
腹腔镜成功切除静脉导管未闭:一例报告
DOI: --
发表时间: 2013
期刊: Surgery Today
影响因子: 2.5
作者: [Yoshiaki Hara, Yoshinobu Sato, Satoshi Yamamoto, et al]
通讯作者: et al
Laparoscope-assisted Hassab's Operation for Esophagogastric Varices After Living Donor Liver Transplantation : A Case Report
腹腔镜辅助哈萨布活体肝移植后食管胃静脉曲张手术:病例报告
DOI: --
发表时间: 2014
期刊: Transplantation Proceedings
影响因子: 0.9
作者: [T. Kobayashi, K. Miura, H. Ishikawa, H. Oya, Y. Sato, et al]
通讯作者: et al
Heterotopic pancreas autotransplantation with spleen for uncontrollable hemorrhagic pseudocyst and disabling pain in chronic pancreatitis
异位胰腺自体移植术治疗慢性胰腺炎无法控制的出血性假性囊肿和致残性疼痛
DOI: --
发表时间: 2013
期刊: Hepatogastroenterol
影响因子: --
作者: [Yoshinobu Sato, Hiroshi Oya, Satoshi Yamamoto, et al]
通讯作者: et al
7
    Decision support for total hip arthroplasty surgery by integration of deep learning, simulations, and statistical models
    • 批准号:
      19H01176
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $28.95万
    • 财政年份:
      2019
    • 负责人:
      SATO Yoshinobu
    • 依托单位:
    A Study on Omotenashi from the Standpoint of Value Co-creation: Clarifying the Process from the Origin to the Modern Phenomena
    • 批准号:
      16K03968
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.75万
    • 财政年份:
      2016
    • 负责人:
      SATO Yoshinobu
    • 依托单位:
    Developing an Education Program for Becoming an Effective Action Researcher
    • 批准号:
      21530428
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.58万
    • 财政年份:
      2009
    • 负责人:
      SATO Yoshinobu
    • 依托单位:
    Atlas-based automated segmentation and anatomical identification of tubular and sheet structures from 3D medical images
    • 批准号:
      21300068
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.73万
    • 财政年份:
      2009
    • 负责人:
      SATO Yoshinobu
    • 依托单位:
    国内基金
    海外基金
    改变炎性微环境构建新型自发结直肠癌小鼠模型及巨噬细胞Act1调控癌化机制研究
    • 批准号:
      31771578
    • 项目类别:
      面上项目
    • 资助金额:
      62.0万元
    • 批准年份:
      2017
    • 负责人:
      王丽京
    • 依托单位:
    突变神经干细胞成瘤前竞争力与区域癌化的研究
    • 批准号:
      81502392
    • 项目类别:
      青年科学基金项目
    • 资助金额:
      22.0万元
    • 批准年份:
      2015
    • 负责人:
      陈坚
    • 依托单位:
    食管癌化HUVECs疫苗联合基于PDX模型的个体化DCs瘤苗抗食管鳞癌研究
    • 批准号:
      81572972
    • 项目类别:
      面上项目
    • 资助金额:
      57.0万元
    • 批准年份:
      2015
    • 负责人:
      路静
    • 依托单位:
    CTCF介导的远距离染色质相互作用对乳腺细胞癌化的表观遗传调控及其机理