The research of mechanisms between shear stress and caveola in the liver regeneration and liver injury

剪切应力和小凹在肝再生和肝损伤中的机制研究

• 批准号: 24659601
• 负责人: SATO Yoshinobu
• 金额: $ 2.41万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659601/
• 关键词: 肝再生; 癌化; 転移; ずり応力; caveolin-1; PAI-1; 脂肪肝; カベオラ; shear stress; 癌増殖転移; 上皮間葉転換; 炎症; 細胞マトリックス; 癌増殖; 免疫

Last year, I changed my work location from Niigata Univ. to Showa Univ. Therefore, I could not perform the scheduled program. We intended to investigate comprehensively about a role of Caveolin-1 and PAI-1 in the liver. The clinicopathological analyses were made in the regenerative liver, steatotic liver, metastatic liver, and primary hepatocellular carcinoma and the mechanisms of regeneration, carcinogenesis, inflammation, and cancer metastasis were studied. Pilot study by immunological staining of the metastatic liver of colon cancer with caveolin-1, PAI-1, MT1-MMP, CD44 were performed. I could recognize the interesting findings that both the specimen of metastatic liver and primary colon cancer in Type 5 of colon cancer revealed the augmentation of PAI-1 staining.

去年，我将工作地点从新泻大学改为昭和大学。因此，我无法执行预定的计划。我们打算全面研究Caveolin-1和派-1在肝脏中的作用。对再生肝、脂肪肝、转移肝和原发性肝癌进行临床病理分析，探讨再生、癌变、炎症和癌转移的机制。应用免疫组化方法对结肠癌肝转移灶进行caveolin-1、派-1、MT 1-MMP、CD 44的初步研究。 我可以认识到有趣的发现，即在5型结肠癌中转移性肝脏和原发性结肠癌的标本均显示派-1染色增强。

项目成果

Catheter-directed continuous thrombolysis following aspiration thrombectomy via the ileocolic route for acute portal venous thrombosis: report of two cases.

经回结肠途径抽吸血栓切除术后导管引导持续溶栓治疗急性门静脉血栓：两例报告。

• 发表时间: 2013
• 期刊: Surgery Today
• 影响因子: 2.5
• 作者: Miura K;Sato Y*;Nakatsuka H;Yamamoto S;Oya H;Hara Y;Kokai H;Hatakeyama K.
• 通讯作者: Hatakeyama K.

Successful laparoscopic division of patent ductus venosus : Report of a Case

腹腔镜成功切除静脉导管未闭：一例报告

• 发表时间: 2013
• 期刊: Surgery Today
• 影响因子: 2.5
• 作者: Yoshiaki Hara;Yoshinobu Sato;Satoshi Yamamoto;et al
• 通讯作者: et al

Laparoscope-assisted Hassab's Operation for Esophagogastric Varices After Living Donor Liver Transplantation : A Case Report

腹腔镜辅助哈萨布活体肝移植后食管胃静脉曲张手术：病例报告

• 发表时间: 2014
• 期刊: Transplantation Proceedings
• 影响因子: 0.9
• 作者: T. Kobayashi;K. Miura;H. Ishikawa;H. Oya;Y. Sato;et al
• 通讯作者: et al

Heterotopic pancreas autotransplantation with spleen for uncontrollable hemorrhagic pseudocyst and disabling pain in chronic pancreatitis

异位胰腺自体移植术治疗慢性胰腺炎无法控制的出血性假性囊肿和致残性疼痛

• 发表时间: 2013
• 期刊: Hepatogastroenterol
• 作者: Yoshinobu Sato;Hiroshi Oya;Satoshi Yamamoto;et al
• 通讯作者: et al

Perioperative immunological differentiation in liver cirrhotic patients who underwent living related liver transplantation

肝硬化患者活体肝移植围术期免疫分化

• 发表时间: 2013
• 期刊: Hepatogastroenterol
• 作者: Sato Y;Tomiyama C;Yamamoto S;et al
• 通讯作者: et al