The development of high molecular substance expressing antibacterial activity derived from active oxygen

源自活性氧的表现抗菌活性的高分子物质的开发

• 批准号: 24659930
• 负责人: MIZUNO Morimichi
• 金额: $ 1.16万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659930/
• 关键词: 活性酸素発生能; 高分子化合物; 殺菌性高分子体; ナノファイバー; 活性酸素; ヒドロキシラジカル

The purpose of the study is development of high molecular substance generating active oxygen and establishment of new oral cleaning system instead of tooth blushing. By the several investigations, the polymer composed of glucose molecule was shown to be a suitable material producing the enough amounts of active oxygen. The polymer producing active oxygen was synthesized by the mixing with 1 M of hydrogen peroxide solution, followed by the removal of water and grinding to make a powder (solid active oxygen powder). The solid active oxygen powder was most stable when their particle size was between 100 and 200 micro-meter.Furthermore, Maillard reaction product (MRP) synthesized from monosaccharide and amino acid promoted the stability of active oxygen exist in solid active oxygen powder. Especially, MRP synthesized from glucose and histidine was most effective to stabilize the active oxygen among investigated MRPs.

本研究的目的是开发能产生活性氧的高分子物质，建立一种新型的口腔清洁系统，以代替牙齿的脸红。 研究表明，由葡萄糖分子组成的聚合物是一种能够产生足够数量活性氧的合适材料。 产生活性氧的聚合物通过与1 M过氧化氢溶液混合，随后除去水并研磨以制备粉末（固体活性氧粉末）来合成。 固体活性氧粉末的粒径在100 ~ 200 μ m时最稳定，单糖与氨基酸合成的美拉德反应产物（MRP）促进了活性氧在固体活性氧粉末中的稳定存在。 尤其是由葡萄糖和组氨酸合成的MRP对活性氧的稳定作用最强。

项目成果

過酸化水素を担持した殺菌性歯科用レジンに対するメラノイジンの効果

类黑素对过氧化氢牙科树脂灭菌的影响

• 发表时间: 2013
• 作者: 水野守道