Develoment of the Balloon cather System for intravasculat Surgery

球囊导管在诊断和治疗血管造影术中的使用现在已被广泛接受。然而，要安全地使用球囊导管，还需要更复杂的系统。本文列举了本研究中所做的改进：1.不透射线的固化液；球囊导管栓塞术中使用的固化液应满足低粘度、抗放射性和合适的固化时间的要求。乙烯基单体和不透射线化学品的混合物满足了Valum的大部分要求。然而，由于氧抑制了自由基聚合，因此聚甲基化不会在血管中进行。在这项研究中，我们开发了一种新的利用酶(葡萄糖氧化酶(GOD))的引发反应。上帝除去氧气，并将其转化为过氧化氢。生成的过氧化氢被Fe(II)分解为羟基自由基。它可以引发树脂聚合。可以通过改变上帝和/或摩尔的…的浓度来很容易地缩短固化时间再加点盐。不透射线的堵塞液；环氧丙烯酸酯是一种非创伤性的使用巴斯隆导管堵住脑动静脉畸形血管的方法。气球有时会被氰基乙酸酯粘在血管上。气囊导管不能拔出。新研制的不透射线堵塞液是乙撑乙烯基醇(EVL)、甲基咪唑胺和二甲基亚砜的混合物。它没有氰基丙烯酸酯的大部分缺点。高频电流源；该电源是专门为从导管上松开气囊而开发的。它可以检测到导管中是否存在导入线短路或断丝，即使存在，也能进一步释放Bal100n。第三节所述的双腔球囊导管是专门用来封堵血管的导管，我们认为这种导管是值得推广的。在这项研究中开发的系统是最复杂和安全的，可用于脑基底病变的包裹化。较少

The use of a balloon catheter in diagnostic and therapeutic angiography id now widely accepted. Howefer, More sophisticated system are desired to use the ballon catheter safely.The improvement done in this research are listed;1. Radiopaque solidigying liquid; Solidifying liquid used in balloon catheter embolization shouls satisfy the requeirements such as low viscosity, radiopague and appropriate solidifying time. The mexture of vinyl monomer and radiopaque chemicals satisties the most of the requirements under valum. However, the polymetization dose not proceed in the blood vessels because the oxygen inhibits the radical polymerization. In this study we developed a new initiation reaction using enzyme(glucose oxidase(GOD)). GOD removes oxygen and conberts it to hydroxy peroxide. The produced hydroxy peroxide is decomposed to a hydroxy radical by Fe(II). It can initiate resical polymerization. The solidifying time can be esaily abjested by changing the concetration of GOD and/or Mohr's … More salt.2. Radiopaque plugging luquid; Cynoacrylate is noventional used to plug blood vessels in cerebral arteriobvencous maiformation using a baslloon catheter. The balloon is sometimes stuck to a blood vessel by cyanoactylate. The balloon catheter can not be removed. Ht nuwly developed radiopaque plugging liquid is a mixture of ehtylene vinyl alcohon(EVL), metrizamide and dimethylsulfoxide. It is free from most of the disadvantages of cyanoacrylate.3. High frequency electrical current supply; The power supply has been especially developed to relase a balloon from catheter. It can detect the presence of shortciruiting ot broken wire of lead-in wires in the catheter and further can release a bal100n even the presence of then.4. The double lumen balloon catheter has been developed especially for plugging blood vessels using mexture mentined in section 3.We believe that the valloon catheter. systems developed in this research is most sophisticate and safely usable for embvolization of cerebrobascular lesions. Less