Surface modification of islets for increasing graft survival rate
胰岛表面修饰以提高移植物成活率
基本信息
- 批准号:21240051
- 负责人:
- 金额:$ 30.37万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (A)
- 财政年份:2009
- 资助国家:日本
- 起止时间:2009 至 2011
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Regenerative medicine and tissue engineering have opened new therapeutic domains. One of the more successful endeavors has been the transplantation of islets of Langerhans(islets), which produce and release insulin, as a treatment for patients with type 1 diabetes. However, when implanted into living tissue, islets can induce various undesirable biological responses, including blood coagulation, complement activation, inflammatory reactions, and immune reactions. We developed a new method in whichproteins and cells are immobilized on the islet surface to increase their compatibility with a host environment. Islet surface is modified with the ssDNA-PEG-lipid. Proteins or cells are modified with a ssDNA' that is complementary to the ssDNA. The proteins or the cells can be immobilized on the cell through hybridization between the ssDNA and ssDNA'.
再生医学和组织工程开辟了新的治疗领域。比较成功的努力之一是移植朗格汉斯胰岛(胰岛),这种胰岛可以产生和释放胰岛素,作为1型糖尿病患者的治疗方法。然而,当胰岛移植到活组织中时,会引起各种不良的生物反应,包括凝血、补体激活、炎症反应和免疫反应。我们开发了一种新的方法,将蛋白质和细胞固定在胰岛表面,以增加它们与宿主环境的相容性。用单链DNA-聚乙二醇脂质体修饰胰岛表面。蛋白质或细胞被与单链DNA互补的单链DNA修饰。通过单链DNA和单链DNA的杂交,可以将蛋白质或细胞固定在细胞上。
项目成果
期刊论文数量(59)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Control of cell attchment through polyDNA hybridization.
通过多聚 DNA 杂交控制细胞附着。
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:Teramura Y.;Chen H.;Kawamoto T.;Iwata H.
- 通讯作者:Iwata H.
Polymeric Biomaterials : Volume II, Medicinal and Pharmaceutical Applications of Polymers
聚合生物材料:第二卷,聚合物的医学和制药应用
- DOI:
- 发表时间:2012
- 期刊:
- 影响因子:0
- 作者:Teramura Y.;Chen H.;Takemoto N.;Sakurai K.;Iwata H
- 通讯作者:Iwata H
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IWATA Hiroo其他文献
IWATA Hiroo的其他文献
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{{ truncateString('IWATA Hiroo', 18)}}的其他基金
Transplantation of islets in immune tolerance site under skin induced by bFGF or SEK-1005
bFGF 或 SEK-1005 诱导的皮下免疫耐受部位移植胰岛
- 批准号:
26670577 - 财政年份:2014
- 资助金额:
$ 30.37万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Evacuation Simulator Using Locomotion Interface
使用运动接口的疏散模拟器
- 批准号:
25240030 - 财政年份:2013
- 资助金额:
$ 30.37万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Transplantation of co-aggregates of islet cells and immune suppressor cells
胰岛细胞和免疫抑制细胞共聚集体的移植
- 批准号:
24240078 - 财政年份:2012
- 资助金额:
$ 30.37万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Study of cell-cell interaction: Cell manipulation method for tissue regeneration
细胞与细胞相互作用的研究:组织再生的细胞操作方法
- 批准号:
23650257 - 财政年份:2011
- 资助金额:
$ 30.37万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Development of Generic Technology of Locomotion Interface
运动接口通用技术的发展
- 批准号:
21240006 - 财政年份:2009
- 资助金额:
$ 30.37万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Development of 3D Infinite Walkthrough Space and its Evaluation
3D无限漫游空间的开发及其评价
- 批准号:
18300040 - 财政年份:2006
- 资助金额:
$ 30.37万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Encapsulation of Islets with Amphiphilic Polymers for Immuno-isolation
用两亲性聚合物封装胰岛以进行免疫隔离
- 批准号:
18200034 - 财政年份:2006
- 资助金额:
$ 30.37万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Development of an Omni-directional Virtual Walk-space and its Evaluation
全方位虚拟步行空间的开发及其评价
- 批准号:
14350126 - 财政年份:2002
- 资助金额:
$ 30.37万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Insulin releasing cells derived from embryonic stem cells and new semipermeable membranes for bioartificial pancreas.
来自胚胎干细胞的胰岛素释放细胞和用于生物人工胰腺的新型半透膜。
- 批准号:
14207048 - 财政年份:2002
- 资助金额:
$ 30.37万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Spatial Recognition Performance Tests Using Omni-directional Infinite Surface
全向无限曲面空间识别性能测试
- 批准号:
11650261 - 财政年份:1999
- 资助金额:
$ 30.37万 - 项目类别:
Grant-in-Aid for Scientific Research (C)