Surface modification of islets for increasing graft survival rate

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Regenerative medicine and tissue engineering have opened new therapeutic domains. One of the more successful endeavors has been the transplantation of islets of Langerhans(islets), which produce and release insulin, as a treatment for patients with type 1 diabetes. However, when implanted into living tissue, islets can induce various undesirable biological responses, including blood coagulation, complement activation, inflammatory reactions, and immune reactions. We developed a new method in whichproteins and cells are immobilized on the islet surface to increase their compatibility with a host environment. Islet surface is modified with the ssDNA-PEG-lipid. Proteins or cells are modified with a ssDNA' that is complementary to the ssDNA. The proteins or the cells can be immobilized on the cell through hybridization between the ssDNA and ssDNA'.