Selective optical sensor arrays in a silicon hybrid platform (SOSAS)

硅混合平台中的选择性光学传感器阵列 (SOSAS)

• 批准号: 420007645
• 负责人: Professor Dr.-Ing. Manfred Berroth
• 金额: --
• 依托单位: Institut für Grenzflächenverfahrenstechnik und Plasmatechnologie IGVP
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/420007645?language=en
• 关键词: Selective; optical; sensor; arrays; silicon

Fast and precise analysis of the composition of liquids and aqueous solutions is extremely important, e.g. in order to detect drug residues in drinking water or to be able to quickly adapt technical process conditions on demand. Today, analysis of mixtures is routinely done by taking samples from the mixtures followed by instrumental analysis. This requires specific instrumental equipment and methodological knowledge and also gives delayed results due to the time necessary for sample transportation to the analysis laboratory. Therefore, in this proposal a sensor based on integrated optical waveguides will be investigated which will be able to analyze the composition of complex mixtures on the spot in one step with a quantitative result. The approach is based on a silicon chip containing an array of waveguides which are sensitive to refractive index changes on their surfaces and have optical read-outs. The chip is the basis of a sensor platform which can be produced cost-effectively in large quantities for versatile uses. Customization of the chip surface for actual sample analysis and the necessary “sensitization” of the individual waveguides is done analyte-specific and spatially resolved by additional coating with functional layers, e.g. by inkjet printing. The aim of the project is to understand the interaction of optical waveguides and functional layers and to optimize the combination of both components, resulting in an operational sensor prototype for the quantitative analysis of complex aqueous solutions. The sensor performance will be demonstrated using aqueous solutions with concentrations as small as possible of the drugs Diclofenac, Carbamazepin, and Metoprolol.

快速和精确地分析液体和水溶液的组成是非常重要的，例如，为了检测饮用水中的药物残留或能够根据需要快速适应技术工艺条件。今天，混合物的分析通常是通过从混合物中取样，然后进行仪器分析来完成的。这需要特定的仪器设备和方法学知识，并且由于样品运输到分析实验室所需的时间而导致结果延迟。因此，本文将研究一种基于集成光波导的传感器，该传感器将能够在现场一步分析复杂混合物的组成并获得定量结果。这种方法是基于一个包含波导阵列的硅芯片，这些波导对其表面的折射率变化很敏感，并且具有光学读出。该芯片是传感器平台的基础，可以经济高效地大批量生产，用于多种用途。为实际样品分析定制芯片表面，并对单个波导进行必要的“敏化”，通过附加的功能层涂层（例如喷墨打印）完成特定于分析物和空间的解决。该项目的目的是了解光波导和功能层的相互作用，并优化这两个组件的组合，从而产生用于复杂水溶液定量分析的可操作传感器原型。传感器的性能将用浓度尽可能小的双氯芬酸、卡马西平和美托洛尔的水溶液来证明。