RESEARCH OF ARTIFICIAL LIVER SUPPORT SYSTEM

网状内皮系统（RES）在严重感染的生存中起着关键作用。本实验采用肝枯否细胞（Kupffer cell，RES）选择性抑制剂GdCl_3，从肝细胞能量代谢和枯否细胞产生超氧阴离子能力两方面，分析了RES在内毒素血症大鼠体内和体外的作用。这项研究的结果将发表在Leucocyte Biology上。另一项对70%和90%肝切除大鼠的实验也表明，由于严重感染引起的肝脏RES过度激活的镇静可能导致70%肝切除大鼠的存活率提高，但在肝细胞功能质量不足的90%肝切除大鼠中，GdCl_3没有显示任何改善。

The reticuloendothelial system (RES) has the pivotal role for survival in severe infection. Using GdCl_3 that is an selective inhibitor of the liver RES (Kupffer cell) we analyzed roles of RES in endotoxemic rats in vivo and in vitro, referring to the energy metabolism of hepatocytes and the capability of superoxide production of the isolated Kupffer cells. The result of this study will be published in Leucocyte Biology. Another experiment with 70%- and 90%-hepatectomized rats also indicated that sedation of overactivation of RES in the liver due to severe infection may lead to improve the survival rate of 70%-hepatectomized rats but in 90%-hepatectomized rats which had an insufficient functioning mass of the hepatocyte GdCl_3 did not show any improvement.